Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features

A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3...

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Bibliographic Details
Published in:Orbit (Amsterdam) 2024-02, Vol.43 (1), p.105-108
Main Authors: Sun, Jing, Campbell, Benjamin C, Burgin, Sarah J, Lee, H B Harold, Alomari, Ahmed K, Klapper, Stephen R
Format: Article
Language:English
Subjects:
Adenocarcinoma, Sebaceous - diagnostic imaging
Adenocarcinoma, Sebaceous - pathology
Adenocarcinoma, Sebaceous - surgery
Carcinoma, Neuroendocrine - diagnostic imaging
Carcinoma, Neuroendocrine - surgery
Eyelid Neoplasms - pathology
Female
Humans
Middle Aged
Orbital Neoplasms - diagnostic imaging
Orbital Neoplasms - surgery
Sebaceous Gland Neoplasms - diagnostic imaging
Sebaceous Gland Neoplasms - surgery
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Summary:A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3.5 cm that abutted the globe with extensive conjunctival involvement. Neuroimaging demonstrated lesions concerning for parotid gland metastases. An incisional biopsy demonstrated synaptophysin-positive small blue cells concerning for neuroendocrine carcinoma. The patient underwent orbital exenteration with parotidectomy and radical neck dissection. The excised mass was found to have distinct neuroendocrine carcinoma cells intermingled with sebaceous carcinoma cells, a combination not previously reported.
ISSN:0167-6830
1744-5108
DOI:10.1080/01676830.2022.2078843