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Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features
A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3...
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| Published in: | Orbit (Amsterdam) 2024-02, Vol.43 (1), p.105-108 |
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| cites | cdi_FETCH-LOGICAL-c257t-af240f731f7486f5e427299e9010fce716e0bcaab52c252fdb2655f433420943 |
| container_end_page | 108 |
| container_issue | 1 |
| container_start_page | 105 |
| container_title | Orbit (Amsterdam) |
| container_volume | 43 |
| creator | Sun, Jing Campbell, Benjamin C Burgin, Sarah J Lee, H B Harold Alomari, Ahmed K Klapper, Stephen R |
| description | A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3.5 cm that abutted the globe with extensive conjunctival involvement. Neuroimaging demonstrated lesions concerning for parotid gland metastases. An incisional biopsy demonstrated synaptophysin-positive small blue cells concerning for neuroendocrine carcinoma. The patient underwent orbital exenteration with parotidectomy and radical neck dissection. The excised mass was found to have distinct neuroendocrine carcinoma cells intermingled with sebaceous carcinoma cells, a combination not previously reported. |
| doi_str_mv | 10.1080/01676830.2022.2078843 |
| format | article |
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She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3.5 cm that abutted the globe with extensive conjunctival involvement. Neuroimaging demonstrated lesions concerning for parotid gland metastases. An incisional biopsy demonstrated synaptophysin-positive small blue cells concerning for neuroendocrine carcinoma. The patient underwent orbital exenteration with parotidectomy and radical neck dissection. The excised mass was found to have distinct neuroendocrine carcinoma cells intermingled with sebaceous carcinoma cells, a combination not previously reported.</description><identifier>ISSN: 0167-6830</identifier><identifier>EISSN: 1744-5108</identifier><identifier>DOI: 10.1080/01676830.2022.2078843</identifier><identifier>PMID: 35635143</identifier><language>eng</language><publisher>England</publisher><subject>Adenocarcinoma, Sebaceous - diagnostic imaging ; Adenocarcinoma, Sebaceous - pathology ; Adenocarcinoma, Sebaceous - surgery ; Carcinoma, Neuroendocrine - diagnostic imaging ; Carcinoma, Neuroendocrine - surgery ; Eyelid Neoplasms - pathology ; Female ; Humans ; Middle Aged ; Orbital Neoplasms - diagnostic imaging ; Orbital Neoplasms - surgery ; Sebaceous Gland Neoplasms - diagnostic imaging ; Sebaceous Gland Neoplasms - surgery</subject><ispartof>Orbit (Amsterdam), 2024-02, Vol.43 (1), p.105-108</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c257t-af240f731f7486f5e427299e9010fce716e0bcaab52c252fdb2655f433420943</cites><orcidid>0000-0001-5366-9080</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35635143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Jing</creatorcontrib><creatorcontrib>Campbell, Benjamin C</creatorcontrib><creatorcontrib>Burgin, Sarah J</creatorcontrib><creatorcontrib>Lee, H B Harold</creatorcontrib><creatorcontrib>Alomari, Ahmed K</creatorcontrib><creatorcontrib>Klapper, Stephen R</creatorcontrib><title>Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features</title><title>Orbit (Amsterdam)</title><addtitle>Orbit</addtitle><description>A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. 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The excised mass was found to have distinct neuroendocrine carcinoma cells intermingled with sebaceous carcinoma cells, a combination not previously reported.</description><subject>Adenocarcinoma, Sebaceous - diagnostic imaging</subject><subject>Adenocarcinoma, Sebaceous - pathology</subject><subject>Adenocarcinoma, Sebaceous - surgery</subject><subject>Carcinoma, Neuroendocrine - diagnostic imaging</subject><subject>Carcinoma, Neuroendocrine - surgery</subject><subject>Eyelid Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Orbital Neoplasms - diagnostic imaging</subject><subject>Orbital Neoplasms - surgery</subject><subject>Sebaceous Gland Neoplasms - diagnostic imaging</subject><subject>Sebaceous Gland Neoplasms - surgery</subject><issn>0167-6830</issn><issn>1744-5108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRS0EoqXwCSAv2aT4GSdLVPGSKrEpYhk5zlg1SuxgJ0L9exK1sJnZnDuPg9AtJWtKCvJAaK7ygpM1I4xNRRWF4GdoSZUQmZyQc7ScmWyGFugqpS9CCC8EuUQLLnMuqeBL9Pnh3fcIOMTaDbrFtev34MNw6J3Bw9iFMeIfN-yxhzEG8E0w0XnA2jc4Qa0NhDFho6NxPnQaW9DDGCFdowur2wQ3p75Cu-en3eY1276_vG0et5lhUg2ZtkwQqzi1ShS5lSCYYmUJJaHEGlA0B1IbrWvJpgCzTc1yKa3gXDBSCr5C98exfQzTG2moOpcMtK3282EVyxUtS6kUn1B5RE0MKUWwVR9dp-OhoqSalVZ_SqtZaXVSOuXuTivGuoPmP_XnkP8CDrRyVQ</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Sun, Jing</creator><creator>Campbell, Benjamin C</creator><creator>Burgin, Sarah J</creator><creator>Lee, H B Harold</creator><creator>Alomari, Ahmed K</creator><creator>Klapper, Stephen R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5366-9080</orcidid></search><sort><creationdate>202402</creationdate><title>Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features</title><author>Sun, Jing ; Campbell, Benjamin C ; Burgin, Sarah J ; Lee, H B Harold ; Alomari, Ahmed K ; Klapper, Stephen R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-af240f731f7486f5e427299e9010fce716e0bcaab52c252fdb2655f433420943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenocarcinoma, Sebaceous - diagnostic imaging</topic><topic>Adenocarcinoma, Sebaceous - pathology</topic><topic>Adenocarcinoma, Sebaceous - surgery</topic><topic>Carcinoma, Neuroendocrine - diagnostic imaging</topic><topic>Carcinoma, Neuroendocrine - surgery</topic><topic>Eyelid Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Orbital Neoplasms - diagnostic imaging</topic><topic>Orbital Neoplasms - surgery</topic><topic>Sebaceous Gland Neoplasms - diagnostic imaging</topic><topic>Sebaceous Gland Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Jing</creatorcontrib><creatorcontrib>Campbell, Benjamin C</creatorcontrib><creatorcontrib>Burgin, Sarah J</creatorcontrib><creatorcontrib>Lee, H B Harold</creatorcontrib><creatorcontrib>Alomari, Ahmed K</creatorcontrib><creatorcontrib>Klapper, Stephen R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Orbit (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Jing</au><au>Campbell, Benjamin C</au><au>Burgin, Sarah J</au><au>Lee, H B Harold</au><au>Alomari, Ahmed K</au><au>Klapper, Stephen R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features</atitle><jtitle>Orbit (Amsterdam)</jtitle><addtitle>Orbit</addtitle><date>2024-02</date><risdate>2024</risdate><volume>43</volume><issue>1</issue><spage>105</spage><epage>108</epage><pages>105-108</pages><issn>0167-6830</issn><eissn>1744-5108</eissn><abstract>A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. 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| fulltext | fulltext |
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| ispartof | Orbit (Amsterdam), 2024-02, Vol.43 (1), p.105-108 |
| issn | 0167-6830 1744-5108 |
| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adenocarcinoma, Sebaceous - diagnostic imaging Adenocarcinoma, Sebaceous - pathology Adenocarcinoma, Sebaceous - surgery Carcinoma, Neuroendocrine - diagnostic imaging Carcinoma, Neuroendocrine - surgery Eyelid Neoplasms - pathology Female Humans Middle Aged Orbital Neoplasms - diagnostic imaging Orbital Neoplasms - surgery Sebaceous Gland Neoplasms - diagnostic imaging Sebaceous Gland Neoplasms - surgery |
| title | Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features |
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