The clinicopathological features of programmed death ligand-1 expression in colorectal carcinoma

Background Few studies have addressed the clinicopathological features of colorectal cancer (CRC) that express programed death-ligand 1 (PD-L1). Various assays and scoring methodologies were used and thus inconsistent results were obtained. In this study, we aimed to investigate the relationship of...

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Published in:The International journal of biological markers 2022-09, Vol.37 (3), p.322-327
Main Authors: Al-Jussani, Ghada N., Alsughayer, Anas, Yousuf, Mustafa S., Mullahuwash, Yaseen, Dabbagh, Tamara, Sughayer, Maher A.
Format: Article
Language:English
Subjects:
Biomarkers
Colorectal cancer
Colorectal carcinoma
Immunotherapy
Ligands
Localization
Medical records
Mismatch repair
Monoclonal antibodies
PD-L1 protein
Tumors
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Summary:Background Few studies have addressed the clinicopathological features of colorectal cancer (CRC) that express programed death-ligand 1 (PD-L1). Various assays and scoring methodologies were used and thus inconsistent results were obtained. In this study, we aimed to investigate the relationship of PD-L1 expression in CRC with various clinicopathological variables using a standardized assay and scoring algorithm. Design Tissue microarrays were constructed from 91 random cases of CRC diagnosed at King Hussein Cancer Center (KHCC). Immunohistochemical (IHC) staining using the monoclonal antibody 22C3 was performed. Scoring using the standard “Combined Positive Score” (CPS) method was done. CPS of ≥1 was considered positive. Various clinicopathological features were collected from the medical records of the patients. Results Of the 91 cases, 49 (53.8%) were PD-L1 positive (CPS ≥1). PD-L1 expression was more frequent among moderately differentiated carcinomas (43 of 72 (59.7%) were positive compared to 6 of 19 (31.5%) poorly differentiated cases (P = 0.029)); among node negative cases (21 of 24 (87.5%) N0 cases were PD-L1 positive in contrast to 28 of 67 (41.8%) N1/N2 cases (P = 
ISSN:0393-6155
1724-6008
DOI:10.1177/03936155221104122