Oral delivery of marine shellfish supramolecule peptides for skin wound healing

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2022-08, Vol.216, p.112592-112592, Article 112592
• Main Authors: Yang, Faming, Zhao, Di, Zhang, Kun, Wang, Zhouchi, Wang, Yuxin, Wu, Changcheng, Cui, Shenghao, Guo, Tingting, Chen, Liqi, Chen, Jingdi
• Format: Article
• Language: English
• Subjects: Gut flora; Marine shellfish meat; Randomized peptide self-assembly; Skin wound healing
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2022.112592

Oral administration of peptides/proteins with superior efficacy and fewer side effects is the most advantageous route of administration. In this study, we utilized controllable enzymatic (animal protease) hydrolysis technology to prepare active polypeptide self-assembling supramolecular (APs) from marine shellfish meat to explore the functional mechanism of APs in in vitro and in vivo (oral administration) experiments . In vitro experiments revealed that APs with self-assembly tendency had multifunctional activities. In vivo experiments indicated that oral administration of naturally safe APs could inhibited inflammation, promoted fibroblast proliferation and revascularization, and accelerated the epithelialization process, thus favoring a balanced repair tissue collagen I/III ratio and the promotion of hair follicle regeneration to achieve scarless healing, which was also relevant to "skin-gut" axis. These results showed that APs, as demonstrated in this study, promoted dermal wound healing in mice and may be developed and used to treat skin wounds. [Display omitted] •Randomized peptide self-assembled supramolecules were named and obtained.•Antioxidant, pro-coagulant and cell-proliferating effects were found in APs in vitro.•Oral administration of APs (AAPs and CAPs) can promote healing.•APs have no effect on intestinal structure and has potential healing functions.