Shared pathophysiology: Understanding stroke and Alzheimer’s disease

Alzheimer’s disease and stroke share several known vascular risk factors. The pathophysiology and whether one predisposes to the other is a topic of ongoing investigation. In this critical review, we highlight what is known about each pathway and the shared potential mechanisms. We offer insight int...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2022-07, Vol.218, p.107306-107306, Article 107306
Main Authors: Sriram, Sai, Mehkri, Yusuf, Quintin, Stephan, Lucke-Wold, Brandon
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Blood-brain barrier
Catalysts
Cytokines
Hypotheses
Neurodegeneration
Neurodegenerative diseases
Neurology
Novel targets
Pathology
Pathophysiology
Proteins
Risk factors
Shared mechanisms
Stroke
Traumatic brain injury
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Summary:Alzheimer’s disease and stroke share several known vascular risk factors. The pathophysiology and whether one predisposes to the other is a topic of ongoing investigation. In this critical review, we highlight what is known about each pathway and the shared potential mechanisms. We offer insight into topics that warrant further investigation. We address topics of both neurodegeneration and secondary cascades. Furthermore, the concept of targeting secondary mechanisms early might be a viable treatment option for ongoing preventative measures. The review is intended to serve as a catalyst for further scientific inquiry into this important topic. •Alzheimer’s disease and stroke share several known vascular risk factors.•Neuroinflammation and oxidative stress pathways are shared by Alzheimer’s and stroke.•Amyloid beta toxicity and vascular pathology are common to Alzheimer’s and stroke.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2022.107306