Optical-based biosensor for detection of oncomarker CA 125, recent progress and current status

• Published in: Analytical biochemistry 2022-10, Vol.655, p.114750-114750, Article 114750
• Main Authors: Valerievich Yumashev, Alexei, Rudiansyah, Mohammad, Chupradit, Supat, Kadhim, Mustafa M., Turki Jalil, Abduladheem, Abdelbasset, Walid Kamal, Suksatan, Wanich, Mireya Romero Parra, Rosario, Fakri Mustafa, Yasser, Abdullaev, Bekhzod, Bidares, Ramtin
• Format: Article
• Language: English
• Subjects: Biosensors; CA 125; Nanomaterial; Ovarian cancer (OV); SPR
• ISSN: 0003-2697; 1096-0309
• DOI: 10.1016/j.ab.2022.114750

Ovarian cancer (OV) is the second most mortal gynecological malignancy. The oncomarker CA125 has been used as the main ovarian cancer marker for diagnosing and screening ovarian cancer in stages I and II. Therefore, sensitive and real-time detection of CA 125 is critical in ovarian cancer monitoring. Various tests are used to diagnose the CA 125. In recent years, modern methods such as biosensor technology have replaced the old tests for rapid, sensitive and specific detection of CA 125. Various types of biosensors are being developed, among which Surface Plasmon resonance (SPR) biosensors are one of the most important and remarkable types. Considering the importance of SPR biosensors in the diagnosis of enocomarker CA 125, the main focus of the present study is to consolidate the research work from the past two decade to the present. Also, the advantages and challenges in SPR biosensors development have been considered in the detection of CA 125 oncomarker. [Display omitted] •Ovarian cancer (OC) is a group of maladies that originates in the ovaries, or the associated areas of the fallopian tubes and the peritoneum.•CA125 is a severely glycosylated type I transmembrane protein that is overexpressed in several tumors and pancreatic.•Several types of biosensors, have been developed in numerous fields, and medical sciences.