Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats

• Published in: Biomedicine & pharmacotherapy 2022-07, Vol.151, p.113131-113131, Article 113131
• Main Authors: da Purificação, Natan Reyges Castro, Garcia, Vinícius Barreto, Frez, Flávia Cristina Vieira, Sehaber, Camila Caviquioli, Lima, Kaio Ramon De Aguiar, de Oliveira Lima, Marília Fabiana, de Carvalho Vasconcelos, Roseane, de Araujo, Aurigena Antunes, de Araújo Júnior, Raimundo Fernandes, Lacchini, Silvia, de Oliveira, Flávia, Perles, Juliana Vanessa Colombo Martins, Zanoni, Jacqueline Nelisis, de Sousa Lopes, Maria Luiza Diniz, Clebis, Naianne Kelly
• Format: Article
• Language: English
• Subjects: Antioxidants; Collagen; Diabetes; Myocardium
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2022.113131

This study aimed to analyze the effects of the quercetin (100 mg/kg), 1% glutamine and 1% α-tocopherol antioxidants in the myocardium of rats with streptozotocin-induced diabetes mellitus. Twenty male rats were subdivided into four groups (n = 5): N (normoglycemic); D (diabetic); NT (normoglycemic treated with antioxidants); and DT (diabetic treated with antioxidants) treated for 60 days. Clinical parameters, oxidative stress markers, inflammatory cytokines, myocardial collagen fibers and immunoexpression of superoxide dismutase 1 (SOD-1), glutathione peroxidase-1 (GPx-1), interleukin-1β (IL-1-β), transforming growth factor-beta (TGF-β), and fibroblast growth factor-2 (FGF-2) were evaluated. Results showed reduced body weight, hyperphagia, polydipsia and hyperglycemic state in groups D and DT. The levels of glutathione (GSH) were higher in NT and DT compared to N (p