A Novel AgI‐DNA Rod Comprising a One‐Dimensional Array of 11 Silver Ions within a Double Helical Structure

DNA/RNA duplexes containing metal‐ion‐mediated base pairs (metallo‐base pairs) have potential applications in developing nucleic acid‐based nanodevices and genetic code expansion. Many metallo‐base pairs are formed within duplexes stabilized by Watson–Crick base pairs. Recently, the crystal structur...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-08, Vol.61 (31), p.e202204798-n/a
Main Authors: Atsugi, Takahiro, Ono, Akira, Tasaka, Miho, Eguchi, Natsumi, Fujiwara, Shoji, Kondo, Jiro
Format: Article
Language:English
Subjects:
Ag-DNA Rod
Ag-DNA Wire
Arrays
Base pairs
Circular dichroism
Crystal Structure
Crystals
Deoxyribonucleic acid
Dichroism
DNA
DNA structure
Double-stranded
Genetic code
Ions
Mass spectrometry
Mass spectroscopy
Metallo-Base Pairs
Metallo-DNA
Metallography
Nanotechnology
Nanotechnology devices
Nanowires
NMR
Nuclear magnetic resonance
Nucleic acids
Rods
Silver
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:DNA/RNA duplexes containing metal‐ion‐mediated base pairs (metallo‐base pairs) have potential applications in developing nucleic acid‐based nanodevices and genetic code expansion. Many metallo‐base pairs are formed within duplexes stabilized by Watson–Crick base pairs. Recently, the crystal structure of an AgI‐DNA nanowire with an uninterrupted one‐dimensional silver array was determined. Here, we present a new DNA helical wire, the “AgI‐DNA rod”, containing an uninterrupted array of 11 AgI ions. The AgI‐DNA rod consisted of only C‐AgI‐C, G‐AgI‐G, G‐AgI‐5‐bromouracil (BrU), and BrU‐AgI‐BrU metallo base pairs, with no Watson–Crick pairs. The AgI‐DNA rods were connected by non‐canonical G–G pairs in crystals. Notably, data from our absorbance, circular dichroism, nuclear magnetic resonance, and mass spectrometry analyses suggested that the AgI‐DNA rods formed in solution, as well as within crystals. A novel AgI‐DNA rod comprising a one‐dimensional array of 11 silver ions within a double‐helical structure was obtained by mixing an oligonucleotide and silver ions in appropriate solutions. Furthermore, formations of the rod structure in solutions were determined by UV/Vis, CD, NMR, and mass spectrometry.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202204798