Men With Chronic Orchialgia Exhibit Differential Neuroinflammatory Gene Expression Relative to Asymptomatic Controls

To identify differences in neuroinflammatory gene expression in individuals with chronic orchialgia (CO) compared to asymptomatic controls. Vas deferens, spermatic cord fascia, blood, and urine were collected from 9 men with CO at time of microscopic spermatic cord denervation and 7 asymptomatic con...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2022-08, Vol.166, p.159-163
Main Authors: Werneburg, Glenn T., Keslar, Karen S., Gotwald, Paige, Doolittle, Johnathan, Vij, Sarah C., Berglund, Ryan, Shoskes, Daniel A
Format: Article
Language:English
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Summary:To identify differences in neuroinflammatory gene expression in individuals with chronic orchialgia (CO) compared to asymptomatic controls. Vas deferens, spermatic cord fascia, blood, and urine were collected from 9 men with CO at time of microscopic spermatic cord denervation and 7 asymptomatic controls at time of vasectomy. RNA was isolated and analyzed with the NanoString Human Neuroinflammation panel. Data were normalized, gene expression fold changes and enriched pathways relative to asymptomatic controls were determined. Gene expression was considered significantly different if there was a >2-fold change and P-value
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2022.05.020