An association of VDR gene polymorphism in hypovitaminosis D mediated secondary hyperparathyroidism in adolescent girls; a tertiary hospital study in central India

• Published in: Steroids 2022-09, Vol.185, p.109054-109054, Article 109054
• Main Authors: Chowdhary, R., Khan, R.B., Masarkar, N., Malik, R., Goel, S.K.
• Format: Article
• Language: English
• Subjects: Adolescent; Hypovitaminosis D; Secondary Hyperparathyroidism; VDR gene polymorphism; Vitamin D
• ISSN: 0039-128X; 1878-5867
• DOI: 10.1016/j.steroids.2022.109054

•Study reports change in BMD in adolescent girls result in health complications.•Change in BMD posed risk for maternal, fetal, and neuronal mortality in pregnancy.•Study reports association of ApaI, FokI, TaqI and BsmI polymorphism.•Genetic polymorphism associated with hypovitaminosis D and SHPT Vitamin D is required to maintain normal serum calcium and phosphate levels that help normal bone mineralization, nerve conduction, muscle contraction, immune function, cell proliferation, and differentiation. Interventions including vitamin D supplementation may not improve vitamin D deficiency, as various complex genomic actions could contribute to vitamin D deficiency in the Indian population. Thus, we assessed hypovitaminosis D’s relationship with vitamin D receptor (VDR) gene polymorphism and evaluated parathyroid hormone (PTH) levels in seemingly healthy adolescent school-going girls. We included 100 school-going girls (aged 12–17 years) studying in four schools of different socio-economic strata of Bhopal, India. The selected participants were divided into four groups based on the school in which they were studying. Blood samples were tested for serum calcium, phosphorus, PTH, ALP, vitamin D 25(OH) D, and albumin levels.VDR polymorphism was detected through the PCR-RFLP. Data were analyzed using the chi-square test, ANOVA, and linear regression. The difference in the age, calcium, ALP, and vitamin D values between the four groups were significant (P