Association of CT findings in patients with hemoperitoneum due to ruptured ovarian cysts with subsequent intervention

• Published in: Emergency radiology 2022-10, Vol.29 (5), p.833-843
• Main Authors: Godbe, Jacqueline, Horowitz, Jeanne M., Nguyen, Edward, Catania, Roberta, Gabriel, Helena, Borhani, Amir A., Watters, Amber, Mazur, Stephany L., Uko, Imo I., Miller, Frank H., Kelahan, Linda C.
• Format: Article
• Language: English
• Subjects: Blood transfusion; Cysts; Emergency Medicine; Imaging; Medicine; Medicine & Public Health; Original Article; Ovaries; Radiology; Sensitivity
• ISSN: 1070-3004; 1438-1435
• DOI: 10.1007/s10140-022-02062-0

Purpose Hemoperitoneum caused by ovarian cyst rupture may necessitate intervention. The literature is lacking in descriptions of CT findings that help guide patient management. The purpose of this study is to consider CT findings associated with a need for intervention (surgical or interventional radiology management) versus conservative treatment (observation, pain management, and blood transfusions). Methods Two radiologists retrospectively and independently reviewed 103 CTs of pre-menopausal women who presented with acute hemoperitoneum related to ruptured ovarian cysts between January 2010 and January 2019. The following imaging features were assessed: ovarian cyst characteristics, sentinel clot, contrast extravasation, and hemoperitoneum size. Findings were correlated with patient demographics, clinical parameters, and management with surgery/interventional radiology procedure (intervention group) versus conservative management (conservative group). Results Of the 103 patients with hemoperitoneum from cyst rupture, 16% ( n  = 16) required intervention, and 84% underwent conservative treatment ( n  = 87). Length of stay ( p  = .008) was higher in the intervention group. Statistically significant CT findings in the intervention versus conservative group included ( p -value reader 1/ p -value reader 2) greatest AP dimension of hemoperitoneum ( p  = .001/ p  = 0.02), posterior cul-de-sac AP dimension ( p  = 0.03/ p  = .006), total cul-de-sac AP dimension ( p  = .002/ p  = .007), and number of spaces with hemoperitoneum ( p  = .01/ p  = .02). There was good to excellent inter-reader agreement for these findings (ICC 0.68–0.91). Active contrast extravasation was significant for one reader ( p  = .02) with poor inter-reader agreement (ICC 0.36). In utilizing ROC curves, thresholds of 107 mm (greatest axial AP dimension of hemoperitoneum) yielded a sensitivity and specificity of 0.81 and 0.62 for reader 1 and 0.69 and 0.55 for reader 2; 45 mm (posterior cul-de-sac AP dimension) yielded a sensitivity and specificity of 0.75 and 0.63 for reader 1 and 0.94 and 0.49 for reader 2; 70 mm (total cul-de-sac AP dimension) yielded a sensitivity and specificity of 0.75 and 0.64 for reader 1 and 0.75 and 0.50 for reader 2; and greater than 5 spaces yielded a sensitivity and specificity of 0.75 and 0.58 for reader 1 and 0.69 and 0.70 for reader 2. Conclusion CT findings associated with intervention in hemoperitoneum due to ovarian cyst rupture include size of hemoperitone