ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer

Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs 125I2 and the resulting radioactive host–guest complex exhibits in vitro cytotoxicity com...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-06, Vol.58 (49), p.6942-6945
Main Authors: Xin-Xin, Tian, Yi-Tong, Liu, Li, Yan, Xin-Yu, Qiu, Zhang, Wen-Hua, Young, David J, Chen, Qiu
Format: Article
Language:English
Subjects:
Cations
Colon
Defects
Radiation therapy
Supramolecular compounds
Toxicity
Online Access:Get full text
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Summary:Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs 125I2 and the resulting radioactive host–guest complex exhibits in vitro cytotoxicity comparable to that of Na125I against colon cancer cell line CT26.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc07304d