Association of Aggression and Antiepileptic Drugs: Analysis Using the Japanese Adverse Drug Event Report (JADER) Database

Aggression is the most common adverse effect of antiepileptic drugs (AEDs). This study aimed to investigate the association of aggression with AED use. The reporting odds ratio (ROR) from adverse event reports, submitted to the Japanese Adverse Drug Event Report database between 2004 and 2020, was u...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2022/06/01, Vol.45(6), pp.720-723
Main Authors: Kawada, Kei, Ishida, Tomoaki, Jobu, Kohei, Ohta, Tsuyoshi, Fukuda, Hitoshi, Morisawa, Shumpei, Kawazoe, Tetsushi, Tamura, Naohisa, Miyamura, Mitsuhiko
Format: Article
Language:English
Subjects:
Aggression
Antiepileptic agents
antiepileptic drug
Carbamazepine
Etiracetam
Japanese Adverse Drug Event Report database
Lamotrigine
levetiracetam
Patients
perampanel
Valproic acid
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Summary:Aggression is the most common adverse effect of antiepileptic drugs (AEDs). This study aimed to investigate the association of aggression with AED use. The reporting odds ratio (ROR) from adverse event reports, submitted to the Japanese Adverse Drug Event Report database between 2004 and 2020, was used to calculate and investigate the association between AEDs and aggression. We also analyzed the association of aggression with the combined use of AEDs and the relationship between AED-associated aggression and patient characteristics. A total of 433 patients developed aggression. Significant aggression signals were detected for perampanel (crude ROR: 325.04, 95% confidence interval (CI): 118.48–752.58, p 
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b21-00954