Amiodarone-induced cutaneous leukocytoclastic vasculitis: a case report and a review of the literature

Amiodarone can be used in a variety of arrhythmias. Given its widespread use, the probability of clinicians encountering its cutaneous adverse effects is high. A few cases of amiodarone-induced cutaneous vasculitis were reported in the literature, probably because it is underdiagnosed in clinical pr...

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Bibliographic Details
Published in:Clinical rheumatology 2022-09, Vol.41 (9), p.2875-2881
Main Authors: Ak, Tumay, Algan, Rumeysa Nur, Agirgol, Senay, Hascicek, Seyhan Ozakkayunlu, Turkoglu, Zafer
Format: Article
Language:English
Subjects:
Amiodarone
Biopsy
Cardiac arrhythmia
Case Based Review
Case reports
Clinical medicine
Dermatitis
Drug dosages
Iodine
Literature reviews
Lupus
Medicine
Medicine & Public Health
Patients
Rheumatology
Ulcers
Vasculitis
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Summary:Amiodarone can be used in a variety of arrhythmias. Given its widespread use, the probability of clinicians encountering its cutaneous adverse effects is high. A few cases of amiodarone-induced cutaneous vasculitis were reported in the literature, probably because it is underdiagnosed in clinical practice. Indeed, amiodarone-related cutaneous reactions may present a wide range of manifestations and are sometimes difficult to diagnose. Herein, we report a case with a sizeable necrotic ulcer on the left lower leg shortly after amiodarone exposure. A rigorous diagnostic study was performed before concluding the diagnosis of amiodarone-induced cutaneous vasculitis, which showed the histopathological features of leukocytoclastic vasculitis. The lesion was almost completely healed by the third month of discontinuation of amiodarone. We did a literature search and found seven cases which were reported as leukocytoclastic or lymphocytic vasculitis. We reviewed previous cases and presented our case in comparison to prior cases.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-022-06231-x