Withania somnifera (Ashwagandha) root extract counteract acute and chronic impact of γ-radiation on liver and spleen of rats

The exposure to ionizing radiation has become inescapably because of increased dependence on radiation to execute works in different fields and also its influences on biological systems. Thus, the current study aimed at examination of the radio-protective effect of the natural ashwagandha (Ag) again...

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Published in:Human & experimental toxicology 2022-01, Vol.41, p.9603271221106344-9603271221106344
Main Authors: Azab, Khaled Sh, Maarouf, Rokaya E, Abdel-Rafei, Mohamed K, El Bakary, Nermeen M, Thabet, Noura M
Format: Article
Language:English
Subjects:
Acetylcholine receptors (nicotinic)
Animal tissues
Chronic exposure
Exposure
Gelatinase A
Gelatinase B
Inflammation
Ionizing radiation
Liver
Radiation
Radiation damage
Radiation hazards
Spleen
Structural damage
Tissue inhibitor of metalloproteinase 1
γ Radiation
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container_title Human & experimental toxicology
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creator Azab, Khaled Sh
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description The exposure to ionizing radiation has become inescapably because of increased dependence on radiation to execute works in different fields and also its influences on biological systems. Thus, the current study aimed at examination of the radio-protective effect of the natural ashwagandha (Ag) against acute and chronic doses of γ-radiation on liver and spleen of rats. The impact of Ag was inspected in rats exposed to acute exposure of 8 Gy (single dose) or to chronic exposure of 8 Gy (2 Gy every other day for 4 times). The data obtained reveals significant amelioration of the redox status (MDA, GSH and ROS) in spleen and liver tissues of rats treated with Ag and exposed to the 2-different modes of γ-radiation. Besides, the changes in inflammatory responses assessed by measurements of IL-17, IL-10 and α7-nAchR are less pronounced in rats received Ag and γ-radiation compared to irradiated rats. Further, the measurements of tissues structural damage markers (MMP-2, MMP-9 and TIMP-1) pointed to benefit of Ag against γ-radiation. The histopathological investigation of spleen and liver tissues confirmed this ameliorating action of Ag counter to γ-radiation hazards. It could be suggested that Ashwagandha could exerts radio-protective influences because of its antioxidants and anti-inflammatory capabilities. Graphical Abstract
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ispartof Human & experimental toxicology, 2022-01, Vol.41, p.9603271221106344-9603271221106344
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subjects Acetylcholine receptors (nicotinic)
Animal tissues
Chronic exposure
Exposure
Gelatinase A
Gelatinase B
Inflammation
Ionizing radiation
Liver
Radiation
Radiation damage
Radiation hazards
Spleen
Structural damage
Tissue inhibitor of metalloproteinase 1
γ Radiation
title Withania somnifera (Ashwagandha) root extract counteract acute and chronic impact of γ-radiation on liver and spleen of rats
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