ESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children

•Toxicity reduction with outcome preservation is a goal of myeloablative TBI in children.•Fractionated TBI of 12–14.4 Gy, in 1.6–2 Gy fractions b.i.d. is advisable for children.•When possible, dose reduction to lungs (

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Bibliographic Details
Published in:Radiotherapy and oncology 2022-08, Vol.173, p.119-133
Main Authors: Hoeben, Bianca A.W., Pazos, Montserrat, Seravalli, Enrica, Bosman, Mirjam E., Losert, Christoph, Albert, Michael H., Boterberg, Tom, Ospovat, Inna, Mico Milla, Soraya, Demiroz Abakay, Candan, Engellau, Jacob, Jóhannesson, Vilberg, Kos, Gregor, Supiot, Stéphane, Llagostera, Camille, Bierings, Marc, Scarzello, Giovanni, Seiersen, Klaus, Smith, Ed, Ocanto, Abrahams, Ferrer, Carlos, Bentzen, Søren M., Kobyzeva, Daria A., Loginova, Anna A., Janssens, Geert O.
Format: Article
Language:English
Subjects:
Consensus recommendations
Hematopoietic stem cell transplantation
Pediatric
Total Body Irradiation
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Summary:•Toxicity reduction with outcome preservation is a goal of myeloablative TBI in children.•Fractionated TBI of 12–14.4 Gy, in 1.6–2 Gy fractions b.i.d. is advisable for children.•When possible, dose reduction to lungs (
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2022.05.027