Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food...

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Bibliographic Details
Published in:Trends in parasitology 2022-08, Vol.38 (8), p.614-617
Main Authors: Tandoh, Kwesi Z., Morang'a, Collins M., Wilson, Michael, Quashie, Neils B., Duah-Quashie, Nancy O.
Format: Article
Language:English
Subjects:
artemisinin resistance
extracellular vesicles
hypothetical model
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Summary:Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2022.05.004