Effect of systemic antibiotic therapy on pulp repair following extrusive luxation and avulsion in a murine model: A histomorphological study

• Published in: Dental traumatology 2022-10, Vol.38 (5), p.397-409
• Main Authors: Queiroz, Alfredo Franco, Hidalgo, Mirian Marubayashi, Consolaro, Alberto, Panzarini, Sônia Regina, França, Alline Batistussi, Melo, Moriel Evangelista, Poi, Wilson Roberto
• Format: Article
• Language: English
• Subjects: Amoxicillin; animal model; Animal models; Antibiotics; Dental pulp; Dentin; Inflammation; Injuries; Necrosis; Penicillin; Recovery (Medical); Teeth; tetracycline; tooth replantation; tooth repositioning
• ISSN: 1600-4469; 1600-9657
• DOI: 10.1111/edt.12771

Background/Aim The evidence for any benefit of systemic antibiotic therapy on pulp survival following extrusive luxation and avulsion is inconclusive. The aim of this study was to evaluate the effect of systemic antibiotic therapy with amoxycillin and tetracycline for 7 days on different aspects of dental pulp repair in a murine model. Material and Methods The right maxillary incisor of 180 4 to 8‐week‐old male Wistar rats underwent extrusive luxation or avulsion. The animals were then treated with saline solution (control), tetracycline, or amoxicillin administered intra‐gastrically for 7 days, and euthanized at 7, 15, and 30 days post‐operatively. The layer of odontoblast cells, reparative dentin deposition, Hertwig's epithelial root sheath, pulp necrosis, and periapical inflammatory infiltrate were histomorphologically analyzed and scored. Mann–Whitney, Kruskal–Wallis, and Dunn tests were used to compare mean scores for the different procedures, treatments, and times (p ≤ .05). Results Significant differences were observed between luxated and avulsed teeth (p