Value of 3-T MR imaging in intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma

• Published in: European radiology 2022-12, Vol.32 (12), p.8276-8284
• Main Authors: Sotozono, Hidemitsu, Kanki, Akihiko, Yasokawa, Kazuya, Yamamoto, Akira, Sanai, Hiroyasu, Moriya, Kazunori, Tamada, Tsutomu
• Format: Article
• Language: English
• Subjects: Biomarkers; Body mass; Body mass index; Body size; Cancer; Diabetes mellitus; Diagnostic Radiology; Gastrointestinal; Hemoglobin; Imaging; Internal Medicine; Interventional Radiology; Invasiveness; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Muscles; Neuroradiology; Pancreas; Pancreatic cancer; Pancreatic carcinoma; Parenchyma; Proton density (concentration); Radiology; Risk analysis; Risk factors; Tumors; Ultrasound
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-022-08881-6

Objectives To examine the value of 3-T MRI for evaluating the difference between the pancreatic parenchyma of intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma (IPMN-IC) and the pancreatic parenchyma of patients without an IPMN-IC. Methods A total of 132 patients underwent abdominal 3-T MRI. Of the normal pancreatic parenchymal measurements, the pancreas-to-muscle signal intensity ratio in in-phase imaging (SIR-I), SIR in opposed-phase imaging (SIR-O), SIR in T2-weighted imaging (SIR-T2), ADC (×10 −3 mm 2 /s) in DWI, and proton density fat fraction (PDFF [%]) in multi-echo 3D DIXON were calculated. The patients were divided into three groups (normal pancreas group: n = 60, intraductal papillary mucinous neoplasm (IPMN) group: n = 60, IPMN-IC group: n = 12). Results No significant differences were observed among the three groups in age, sex, body mass index, prevalence of diabetes mellitus, and hemoglobin A1c ( p = 0.141 to p = 0.657). In comparisons among the three groups, the PDFF showed a significant difference ( p < 0.001), and there were no significant differences among the three groups in SIR-I, SIR-O, SIR-T2, and ADC ( p = 0.153 to p = 0.684). The PDFF of the pancreas was significantly higher in the IPMN-IC group than in the normal pancreas group or the IPMN group ( p < 0.001 and p < 0.001, respectively), with no significant difference between the normal pancreas group and the IPMN group ( p = 0.916). Conclusions These observations suggest that the PDFF of the pancreas is associated with the presence of IPMN-IC. Key Points • The cause and risk factors of IPMN with a concomitant invasive carcinoma have not yet been clarified. • The PDFF of the pancreas was significantly higher in the IPMN-IC group than in the normal pancreas group or the IPMN group. • Pancreatic PDFF may be a potential biomarker for the development of IPMN with a concomitant invasive carcinoma.