Stability of a half-sandwich Os() complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A

In the presence of carboxypeptidase, the hydrolytically stable complex [Os(η 6 -pcym)( L2 )Cl]PF 6 ( 2 ) partially released the bioactive substituent indomethacin, bound through the amide bond to the chelating 2-(1,3,4-thiadiazol-2-yl)pyridine-based moiety of L2 . Stability in the presence of other...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2022-06, Vol.51 (24), p.9213-9217
Main Authors: Masaryk, Lukáš, Muthná, Darina, Halaš, Petr, Zoufalý, Pavel, Peterová, Eva, Havelek, Radim, Drahoš, Bohuslav, Milde, David, Mrkvicová, Alena, Štarha, Pavel
Format: Article
Language:English
Subjects:
Biomolecules
Chelation
Coordination compounds
Nicotinamide adenine dinucleotide
Stability
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Summary:In the presence of carboxypeptidase, the hydrolytically stable complex [Os(η 6 -pcym)( L2 )Cl]PF 6 ( 2 ) partially released the bioactive substituent indomethacin, bound through the amide bond to the chelating 2-(1,3,4-thiadiazol-2-yl)pyridine-based moiety of L2 . Stability in the presence of other relevant biomolecules (GSH, NADH, GMP) and cancer cell viability were also studied. The hydrolytically stable half-sandwich complex [Os(η 6 -pcym)(L2)Cl]PF 6 ( 2 ) partially releases the bioactive substituent indomethacin in the presence of carboxypeptidase A.
ISSN:1477-9226
1477-9234
DOI:10.1039/d2dt01085b