Relationship between T-wave amplitude and oxygen pulse in guinea pigs in hyperbaric helium and hydrogen

Albert R. Behnke Diving Medicine Research Center, Naval Medical Research Institute, Bethesda, Maryland 20889-5607 Diving is known to induce a change in the amplitude of the T wave (A Tw ) of electrocardiograms, but it is unknown whether this is linked to a change in cardiovascular performance. We an...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 1998-09, Vol.85 (3), p.798-806
Main Authors: Kayar, Susan R, Parker, Erich C, Aukhert, Eugenia O
Format: Article
Language:English
Subjects:
Air Pressure
Anatomy & physiology
Animals
Applied physiology
Biological and medical sciences
Diving - physiology
Electrocardiography
Guinea Pigs
Heart
Heart Rate - physiology
Helium - administration & dosage
Helium - pharmacology
High Pressure Neurological Syndrome - physiopathology
Human physiology applied to population studies and life conditions. Human ecophysiology
Hydrogen - administration & dosage
Hydrogen - pharmacology
Male
Medical sciences
Metabolism
Models, Biological
Oxygen
Oxygen Consumption - physiology
Regression Analysis
Telemetry
Transports. Aerospace. Diving. Altitude
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Summary:Albert R. Behnke Diving Medicine Research Center, Naval Medical Research Institute, Bethesda, Maryland 20889-5607 Diving is known to induce a change in the amplitude of the T wave (A Tw ) of electrocardiograms, but it is unknown whether this is linked to a change in cardiovascular performance. We analyzed A Tw in guinea pigs at 10-60 atm and 25-36°C, breathing 2% O 2 in either helium (heliox; n  = 10) or hydrogen (hydrox; n  = 9) for 1 h at each pressure. Core temperature and electrocardiograms were detected by using implanted radiotelemeters. O 2 consumption rate was measured by using gas chromatography. In a previous study (S. R. Kayar and E. C. Parker. J. Appl. Physiol. 82: 988-997, 1997), we analyzed the O 2 pulse, i.e., the O 2 consumption rate per heart beat, in the same animals. By multivariate regression analysis, we identified variables that were significant to O 2 pulse: body surface area, chamber temperature, core temperature, and pressure. In this study, inclusion of A Tw made a significantly better model with fewer variables. After normalizing for chamber temperature and pressure, the O 2 pulse increased with increasing A Tw in heliox ( P  = 0.001) but with decreasing A Tw in hydrox ( P
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1998.85.3.798