Two new isoflavones from the roots of Sophora tonkinensis

Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis,...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-02, Vol.25 (2), p.163-170
Main Authors: Chen, Dao-Jun, Yuan, Shuang, Zhang, Peng, An, Qiao, Zou, Ji-Bin, Yuan, Chun-Mao, Zhao, Li-Hua, Hu, Zhan-Xing, Hao, Xiao-Jiang
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
anti-TMV
Data analysis
Fabaceae
Glucosidase
isoflavone
Isoflavones
Isoflavones - pharmacology
Plant Roots - chemistry
Quinolizines - analysis
Roots
Sophora - chemistry
Sophora tonkinensis
Tobacco
Viruses
α-Glucosidase
α-glucosidase inhibitory activity
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Summary:Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α-glucosidase inhibitory activity with IC 50 value of 47.4 mg/L.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2077200