Factors associated with discontinuation of pulmonary vasodilator therapy in children with bronchopulmonary dysplasia-associated pulmonary hypertension

• Published in: Journal of perinatology 2022-09, Vol.42 (9), p.1246-1254
• Main Authors: Avitabile, Catherine M., Zhang, Xuemei, Ampah, Steve B., Wang, Yan, Ash, Devon, Nilan, Kathleen, Mercer-Rosa, Laura, Fierro, Julie L., Frank, David B., Gibbs, Kathleen A.
• Format: Article
• Language: English
• Subjects: 692/699/1785; 692/699/75/593; Bronchopulmonary Dysplasia - epidemiology; Cardiac catheterization; Cardiology; Catheterization; Child; Children; Discharge; Dysplasia; Echocardiography; Electronic health records; Gestational age; Heart; Hemodynamics; Hospitalization; Hospitals; Humans; Hypertension; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - etiology; Infant; Infant, Newborn; Intubation; Laboratories; Lung; Lung diseases; Medical records; Medicine; Medicine & Public Health; Neonates; Nitric oxide; Ostomy; Patients; Pediatric Surgery; Pediatrics; Pulmonary arteries; Pulmonary hypertension; Retrospective Studies; Therapy; Tracheostomy; Tracheotomy; Ultrasonic imaging; Vasodilator Agents - therapeutic use; Vasodilators
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/s41372-022-01421-6

Objective To evaluate factors associated with discontinuation of pulmonary vasodilator therapy in bronchopulmonary dysplasia-related pulmonary hypertension (BPD-PH). Study design Retrospective study of neonatal, echocardiographic, and cardiac catheterization data in 121 infants with BPD-PH discharged on pulmonary vasodilator therapy from 2009–2020 and followed into childhood. Result After median 4.4 years, medications were discontinued in 58%. Those in whom medications were discontinued had fewer days of invasive support, less severe BPD, lower incidence of PDA closure or cardiac catheterization, and higher incidence of fundoplication or tracheostomy decannulation ( p