Sevoflurane sparing effect of morphine in tegus (Salvator merianae) – a preliminary study

This study aimed to determine the minimum anesthetic concentration (MAC) of sevoflurane in tegus (Salvator merianae) and the morphine-sparing effect on this variable. In a prospective, non-blinded, crossover study, MAC was first determined in six tegus under sevoflurane anesthesia alone (MACSEVO) an...

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Published in:Topics in companion animal medicine 2022-09, Vol.50, p.100678-100678, Article 100678
Main Authors: Carregaro, Adriano Bonfim, Bressan, Thais Feres, Xavier, Nathalia Villaça, Silva, André Nicolai E., Justo, André Augusto, Myiashiro, Vitor Yuji, Sanches, Mariana Cardoso
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Blood pressure
Body temperature
Gases
Heart rate
Intubation
lizard
Morphine
opioid
reptile
Salvator merianae
Sevoflurane
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Summary:This study aimed to determine the minimum anesthetic concentration (MAC) of sevoflurane in tegus (Salvator merianae) and the morphine-sparing effect on this variable. In a prospective, non-blinded, crossover study, MAC was first determined in six tegus under sevoflurane anesthesia alone (MACSEVO) and then following intramuscular (IM) administration of morphine (10 mg/kg), administered 3 h before sevoflurane anesthesia (MACSEVO+MOR). A standard bracketing technique was applied to determine the MAC by an electrical supramaximal noxious stimulus (50 Hz, 30 mA) delivered at the base of the tail of the tegus. The end-tidal sevoflurane fraction was reduced or increased by 10% in any evidence of negative or positive motor responses, respectively. The MAC was calculated as the mean of the two highest successive sevoflurane concentrations that permitted positive responses and the two lowest that prevented positive responses. Heart rate, esophageal temperature, and noninvasive mean arterial blood pressure (MAP) were assessed every 10 min. The MAC was significantly different between MACSEVO (2.41 ± 0.06%) and MACSEVO+MORF (1.88 ± 0.43%) (P = 0.007), with a mean ± SD morphine-induced reduction in the sevoflurane MAC of 22 ± 18% (P = 0.0158). Heart rate, MAP, and esophageal temperature did not differ between groups or within groups over time. Results showed that IM premedication with 10 mg/kg morphine produced a sevoflurane sparing effect in tegus with no significant impact on cardiovascular variables.
ISSN:1938-9736
1946-9837
1876-7613
DOI:10.1016/j.tcam.2022.100678