Periosteal chondrosarcoma: A case series in a referral center with survivorship analysis

• Published in: European journal of surgical oncology 2022-08, Vol.48 (8), p.1730-1738
• Main Authors: Pacheco, Marina, Barra, Lucia, Gambarotti, Marco, Magagnoli, Giovanna, Sbaraglia, Marta, Asioli, Sofia, Cocchi, Stefania, Carretta, Elisa, Frisoni, Tommaso, Benini, Stefania, Dei Tos, Angelo Paolo, Righi, Alberto
• Format: Article
• Language: English
• Subjects: Chondrosarcoma; IDH; Periosteal; Prognosis
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2022.05.024

Periosteal chondrosarcomas are among the rarest types of chondrosarcomas dealt with in few small series of cases. In this study, we aimed to present our experience with this chondrosarcoma, seek for prognostic factors for OS and DFS and survey the status of IDH1 and IDH2. 55 periosteal chondrosarcomas were retrospectively identified. Median age was 37 years, there was a male predominance (62%). The great majority of cases involved the metaphysis of long bones of the extremities. The median size of the tumors was 7.5 cm. Thirty patients underwent to subtotal surgical resection, 22 to tangential resection and the remaining 3 to amputation. The margins, reported in 54 cases, were wide/radical in 38 patients (70.4%), marginal in 9 (16.7%) and intralesional in 7 (12.9%). Histologically, 23 (42%) were grade 1; 27 (49%), grade 2; 3 (5%), grade 3 and 2 (4%) were dedifferentiated. A third of cases in which mutational analysis was feasible harbored heterozygous mutations in codon 132 of IDH1. Fifty-four cases were included for follow-up (median, 137 months). Four patients had local recurrences and six patients developed metastasis to the lungs. All patients that developed metastasis died of disease, two died of unrelated causes and 46 were alive without disease. OS and DFS was not found to be statistically associated with clinical and pathological parameters considered. periosteal chondrosarcomas exhibit a low-grade behavior that can be adequately treated with marginal excisions. Clinical and morphologic parameters do not seem to predict their outcome. •Periosteal chondrosarcoma is a neoplasm with a non-aggressive clinical behavior thus, a conservative surgical approach might be adequate.•Neither clinical nor morphologic parameters seem to be predictors of outcome.•Somatic heterozygous mutations of codon 132 of IDH1 are present in approximately 33% of periosteal chondrosarcomas.