Peony-like 3D-MoS2/graphene nanostructures with enhanced mimic peroxidase performance for colorimetric determination of dopamine

• Published in: Talanta (Oxford) 2022-09, Vol.247, p.123553-123553, Article 123553
• Main Authors: Lv, Qian, Chen, Long-sheng, Liu, Hai-xin, Zou, Li-li
• Format: Article
• Language: English
• Subjects: 3D-MoS2/graphene; Colorimetric determination; Dopamine; Mimic peroxidase; Peony-like
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2022.123553

Fast and quantitative detection of dopamine (DA) is highly desirable but still challenging in the clinical diagnosis due to the complexity of the biological samples. Herein, a novel peony-like 3D-MoS2/Graphene (peony-like 3D-MoS2/GR) nanomaterial is designed and characterized. The nanomaterial exhibits outstanding the peroxidase-like activity, which can be employed as a nanozyme for facile and fast colorimetric determination of dopamine. The peony-like 3D-MoS2/GR-based colorimetric assay presents a wide liner dependence on the DA concentration in the range of 1–400 μM and a low detection limit of 0.21 μM. Such excellent results originate from its unique structure, which offers abundant active sites, high specific surface area, interconnected network and the special microenvironment. Furthermore, this reported colorimetric assay is successfully employed for detection of DA in human serum and urine samples. The recovery percentage ranges from 98 to 105.6%. Hence, the peony-like 3D-MoS2/GR paves a new avenue for detection of DA in real biological systems. [Display omitted] Colorimetric determination of dopamine by peony-like 3D-MoS2/Graphene nanozyme. •The as-prepared peony-like 3D-MoS2/Graphene exhibited outstanding peroxidase-like activity.•The superior peroxidase-like activity of peony-like 3D-MoS2/Graphene originated from its unique structure.•Dopamine can be detected with a lower detection limit and broader liner range.