Time course and reaction types of serum IGF-1 and its relationship to BMI and leptin regarding inpatients with anorexia nervosa

Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is in the GH/IGF-I axis. The aim of the study was (a) to investigate longitudinal characteri...

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Bibliographic Details
Published in:Growth hormone & IGF research 2022-06, Vol.64, p.101470-101470, Article 101470
Main Authors: Hellwig-Walter, Christiane, Brune, Maik, Schellberg, Dieter, Buckert, Magdalena, Wesche, Daniela, Cuntz, Ulrich, Friederich, Hans-Christoph, Wild, Beate
Format: Article
Language:English
Subjects:
Anorexia nervosa
Hormonal reaction type
IGF-I
Individual growth models
Leptin
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Summary:Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is in the GH/IGF-I axis. The aim of the study was (a) to investigate longitudinal characteristics of the IGF-I-change during therapy and weight gain in adult AN, (b) to determine relationships between IGF-I and leptin, (c) to characterize patients with weak and pronounced hormonal reactions to underweight. Data was assessed from 19 AN patients. Over the first two months, serum IGF-I concentrations were assessed on a weekly basis; thereafter on a monthly basis. The trend of IGF-I values over time was analyzed using individual growth models. In total, n = 177 IGF-I measurements were analyzed. IGF-I increased significantly dependent on BMI (slope = 20.81, p 
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2022.101470