Reactions of cells to topography

Though contact guidance has been known since the very early days of cell culture very little quantitative examination of the reaction of cells to topography has been made. Exceptions to this subjective approach are given prominence below. Yet if we are to understand how cells react and if we are to...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 1998-01, Vol.9 (12), p.1313-1329
Main Authors: Curtis, Adam S.G., Wilkinson, Chris D.W.
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion - physiology
cell behaviour
Cell Culture Techniques
contact guidance
Cricetinae
Cytoskeleton - physiology
Humans
Macrophages - physiology
Microfabrication
Microscopy, Atomic Force
nanofabrication
Neurites - physiology
Rats
Silicon Dioxide
Surface Properties
tissue engineering
topographical reaction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Though contact guidance has been known since the very early days of cell culture very little quantitative examination of the reaction of cells to topography has been made. Exceptions to this subjective approach are given prominence below. Yet if we are to understand how cells react and if we are to be able to design ideal substrata for particular cells we need this information. Precision and quantitation are required both of the methods of examination of the cells but also in the definition of that topography. Recently it has become clear that the these reactions occur at the nanometric scale and have importance for use in cellular engineering and tissue repair. Topography appears to provide a set of very powerful signals for cells.
ISSN:0920-5063
1568-5624
DOI:10.1163/156856298X00415