Three new hasubanan-type alkaloids from the Stephania longa

Three new hasubanan-type alkaloids, stephalonine Q (1), stephalonine R (2) and stephalonine S (3), together with four known alkaloids, isolonganone (4), eletefine (5), aurantiamide (6), N-cinnamoyltyramine (7), were isolated from the whole plant of . Their structures were identified by NMR, HR-ESI-M...

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Bibliographic Details
Published in:Natural product research 2023-10, Vol.37 (20), p.1-3549
Main Authors: Lin, Rong-Xiao, Fan, Lixia, Chen, Xin, Wu, Jundi, Liu, Zheng, Liu, Fang, Yang, An-Ping, Xia, Chenglai, Liu, Hui, Chen, Hong-Yuan
Format: Article
Language:English
Subjects:
Alkaloids
Crystallography
NMR
Nuclear magnetic resonance
X-ray crystallography
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Summary:Three new hasubanan-type alkaloids, stephalonine Q (1), stephalonine R (2) and stephalonine S (3), together with four known alkaloids, isolonganone (4), eletefine (5), aurantiamide (6), N-cinnamoyltyramine (7), were isolated from the whole plant of . Their structures were identified by NMR, HR-ESI-MS, CD methods and x-ray crystallography, as well as by comparison with the literature data. All isolated compounds were evaluated for their antimicrobial activities against five bacteria . Compound 5 displayed inhibitory activity against only , with an MIC value of 50 μg/mL.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2087221