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Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease
Background Colorectal cancer incidence is rising in adults
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| Published in: | Digestive diseases and sciences 2023-02, Vol.68 (2), p.554-563 |
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| cites | cdi_FETCH-LOGICAL-c442t-58c6c2821d8c9db10422a16319d2d27f1389c6f49d9c1f37f3b524d1f9b90f23 |
| container_end_page | 563 |
| container_issue | 2 |
| container_start_page | 554 |
| container_title | Digestive diseases and sciences |
| container_volume | 68 |
| creator | Patel, Arsheya Krishna, Somashekar G. Patel, Kishan Gray, Darrell M. Mumtaz, Khalid Stanich, Peter P. Hinton, Alice Hussan, Hisham |
| description | Background
Colorectal cancer incidence is rising in adults |
| doi_str_mv | 10.1007/s10620-022-07589-3 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2676921725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A736259413</galeid><sourcerecordid>A736259413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-58c6c2821d8c9db10422a16319d2d27f1389c6f49d9c1f37f3b524d1f9b90f23</originalsourceid><addsrcrecordid>eNp9kU9vFCEYxonR2HX1C3gwJF68TOXPDAzHzaqtSWOTuhdPhOHPSjMDKzAm7Ufop5Zxq43GGA6Ql9_z8L48ALzE6BQjxN9mjBhBDSKkQbzrRUMfgRXuOG1Ix_rHYIUwq2eM2Ql4lvM1QkhwzJ6CE9px1JKOrsDdlc8-7OGVKjbD6OBn-90mCy8Hm325gT7AjZnHkuGXOIe9TXD3VQXYIbiNKdl8iMHAEmG1sQt8HvPBFzX6W1V8DBm6mOCnGJqp1vZBhQLPVC4p-lAfLD6oEb6rWpXtc_DEqTHbF_f7Guw-vN9tz5uLy7OP281Fo9uWlKbrNdOkJ9j0WpgB10GIqoNiYYgh3GHaC81cK4zQ2FHu6NCR1mAnBoEcoWvw5mh7SPHbXHuQk8_ajqMKNs5ZEsaZIJjX71mD13-h13FOteVKcU6FYC1nD9RejVb64GJJSi-mcsMpI51oMa3U6T-ouoydvI7BOl_rfwjIUaBTzDlZJw_JTyrdSIzkkr885i9r_vJn_nIRvbrveB4ma35LfgVeAXoEcr1a8nwY6T-2PwAVqbm8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2773996476</pqid></control><display><type>article</type><title>Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease</title><source>Springer Link</source><creator>Patel, Arsheya ; Krishna, Somashekar G. ; Patel, Kishan ; Gray, Darrell M. ; Mumtaz, Khalid ; Stanich, Peter P. ; Hinton, Alice ; Hussan, Hisham</creator><creatorcontrib>Patel, Arsheya ; Krishna, Somashekar G. ; Patel, Kishan ; Gray, Darrell M. ; Mumtaz, Khalid ; Stanich, Peter P. ; Hinton, Alice ; Hussan, Hisham</creatorcontrib><description><![CDATA[Background
Colorectal cancer incidence is rising in adults < 50 years old, possibly due to obesity. Non-malignant colorectal conditions are understudied in this population. We hypothesize that developing severe obesity in young adulthood also corresponds with increased hospitalization rates for non-malignant colorectal conditions.
Methods
We examined annual percent change (APC) in the prevalence of obesity in adults < 50 using the 2009–2014 National Health and Nutrition Examination Survey. Using the 2010–2014 Nationwide Readmission Database, we then compared yearly hospitalization trends for various gastrointestinal conditions and their outcomes in adults < 50 with severe obesity vs. no obesity.
Results
The prevalence of obesity increased in adults < 50 years in 2009–2014. This increase was most pronounced for severe obesity (APC of + 12.8%). The rate of patients with severe obesity < 50 who were admitted for gastrointestinal diseases has increased by 7.76% per year in 2010–2014 (
p
< 0.001). This increase was > 10% per year for colorectal conditions such Clostridium difficile infections (APC + 17.3%,
p
= 0.002), inflammatory bowel disease (APC + 13.1%,
p
= 0.001), and diverticulitis (APC + 12.7%,
p
= 0.002). The hospitalization rate for chronic liver diseases and acute pancreatitis also increased by 12.2% and 10.0% per year, respectively (
p
< 0.01). In contrast, young adults without obesity had lower hospitalization rate for most gastrointestinal diseases. Furthermore, adults with no obesity had lower mortality rates for appendicitis, diverticulitis, pancreatitis and chronic liver diseases than adults with severe obesity.
Conclusion
Our data suggest that increased adiposity in young adults is associated with more hospitalization and worse outcomes for infectious/inflammatory gastrointestinal conditions. Future prevention strategies are warranted to ameliorate these trends.]]></description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-022-07589-3</identifier><identifier>PMID: 35704253</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute Disease ; Adult ; Adults ; Biochemistry ; Colorectal Neoplasms - epidemiology ; Comparative analysis ; Disease prevention ; Diverticulitis ; Gastroenterology ; Gastrointestinal diseases ; Hepatology ; Hospitalization ; Humans ; Incidence ; Liver ; Liver diseases ; Medicine ; Medicine & Public Health ; Middle Aged ; Nutrition Surveys ; Obesity ; Obesity - epidemiology ; Obesity, Morbid ; Oncology ; Original Article ; Pancreatitis ; Statistics ; Surveys ; Transplant Surgery ; Trends ; Young Adult ; Young adults</subject><ispartof>Digestive diseases and sciences, 2023-02, Vol.68 (2), p.554-563</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-58c6c2821d8c9db10422a16319d2d27f1389c6f49d9c1f37f3b524d1f9b90f23</citedby><cites>FETCH-LOGICAL-c442t-58c6c2821d8c9db10422a16319d2d27f1389c6f49d9c1f37f3b524d1f9b90f23</cites><orcidid>0000-0003-4012-8167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35704253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Arsheya</creatorcontrib><creatorcontrib>Krishna, Somashekar G.</creatorcontrib><creatorcontrib>Patel, Kishan</creatorcontrib><creatorcontrib>Gray, Darrell M.</creatorcontrib><creatorcontrib>Mumtaz, Khalid</creatorcontrib><creatorcontrib>Stanich, Peter P.</creatorcontrib><creatorcontrib>Hinton, Alice</creatorcontrib><creatorcontrib>Hussan, Hisham</creatorcontrib><title>Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description><![CDATA[Background
Colorectal cancer incidence is rising in adults < 50 years old, possibly due to obesity. Non-malignant colorectal conditions are understudied in this population. We hypothesize that developing severe obesity in young adulthood also corresponds with increased hospitalization rates for non-malignant colorectal conditions.
Methods
We examined annual percent change (APC) in the prevalence of obesity in adults < 50 using the 2009–2014 National Health and Nutrition Examination Survey. Using the 2010–2014 Nationwide Readmission Database, we then compared yearly hospitalization trends for various gastrointestinal conditions and their outcomes in adults < 50 with severe obesity vs. no obesity.
Results
The prevalence of obesity increased in adults < 50 years in 2009–2014. This increase was most pronounced for severe obesity (APC of + 12.8%). The rate of patients with severe obesity < 50 who were admitted for gastrointestinal diseases has increased by 7.76% per year in 2010–2014 (
p
< 0.001). This increase was > 10% per year for colorectal conditions such Clostridium difficile infections (APC + 17.3%,
p
= 0.002), inflammatory bowel disease (APC + 13.1%,
p
= 0.001), and diverticulitis (APC + 12.7%,
p
= 0.002). The hospitalization rate for chronic liver diseases and acute pancreatitis also increased by 12.2% and 10.0% per year, respectively (
p
< 0.01). In contrast, young adults without obesity had lower hospitalization rate for most gastrointestinal diseases. Furthermore, adults with no obesity had lower mortality rates for appendicitis, diverticulitis, pancreatitis and chronic liver diseases than adults with severe obesity.
Conclusion
Our data suggest that increased adiposity in young adults is associated with more hospitalization and worse outcomes for infectious/inflammatory gastrointestinal conditions. Future prevention strategies are warranted to ameliorate these trends.]]></description><subject>Acute Disease</subject><subject>Adult</subject><subject>Adults</subject><subject>Biochemistry</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Comparative analysis</subject><subject>Disease prevention</subject><subject>Diverticulitis</subject><subject>Gastroenterology</subject><subject>Gastrointestinal diseases</subject><subject>Hepatology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity, Morbid</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pancreatitis</subject><subject>Statistics</subject><subject>Surveys</subject><subject>Transplant Surgery</subject><subject>Trends</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kU9vFCEYxonR2HX1C3gwJF68TOXPDAzHzaqtSWOTuhdPhOHPSjMDKzAm7Ufop5Zxq43GGA6Ql9_z8L48ALzE6BQjxN9mjBhBDSKkQbzrRUMfgRXuOG1Ix_rHYIUwq2eM2Ql4lvM1QkhwzJ6CE9px1JKOrsDdlc8-7OGVKjbD6OBn-90mCy8Hm325gT7AjZnHkuGXOIe9TXD3VQXYIbiNKdl8iMHAEmG1sQt8HvPBFzX6W1V8DBm6mOCnGJqp1vZBhQLPVC4p-lAfLD6oEb6rWpXtc_DEqTHbF_f7Guw-vN9tz5uLy7OP281Fo9uWlKbrNdOkJ9j0WpgB10GIqoNiYYgh3GHaC81cK4zQ2FHu6NCR1mAnBoEcoWvw5mh7SPHbXHuQk8_ajqMKNs5ZEsaZIJjX71mD13-h13FOteVKcU6FYC1nD9RejVb64GJJSi-mcsMpI51oMa3U6T-ouoydvI7BOl_rfwjIUaBTzDlZJw_JTyrdSIzkkr885i9r_vJn_nIRvbrveB4ma35LfgVeAXoEcr1a8nwY6T-2PwAVqbm8</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Patel, Arsheya</creator><creator>Krishna, Somashekar G.</creator><creator>Patel, Kishan</creator><creator>Gray, Darrell M.</creator><creator>Mumtaz, Khalid</creator><creator>Stanich, Peter P.</creator><creator>Hinton, Alice</creator><creator>Hussan, Hisham</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4012-8167</orcidid></search><sort><creationdate>20230201</creationdate><title>Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease</title><author>Patel, Arsheya ; Krishna, Somashekar G. ; Patel, Kishan ; Gray, Darrell M. ; Mumtaz, Khalid ; Stanich, Peter P. ; Hinton, Alice ; Hussan, Hisham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-58c6c2821d8c9db10422a16319d2d27f1389c6f49d9c1f37f3b524d1f9b90f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Adults</topic><topic>Biochemistry</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Comparative analysis</topic><topic>Disease prevention</topic><topic>Diverticulitis</topic><topic>Gastroenterology</topic><topic>Gastrointestinal diseases</topic><topic>Hepatology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nutrition Surveys</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity, Morbid</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pancreatitis</topic><topic>Statistics</topic><topic>Surveys</topic><topic>Transplant Surgery</topic><topic>Trends</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Arsheya</creatorcontrib><creatorcontrib>Krishna, Somashekar G.</creatorcontrib><creatorcontrib>Patel, Kishan</creatorcontrib><creatorcontrib>Gray, Darrell M.</creatorcontrib><creatorcontrib>Mumtaz, Khalid</creatorcontrib><creatorcontrib>Stanich, Peter P.</creatorcontrib><creatorcontrib>Hinton, Alice</creatorcontrib><creatorcontrib>Hussan, Hisham</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Family Health</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Arsheya</au><au>Krishna, Somashekar G.</au><au>Patel, Kishan</au><au>Gray, Darrell M.</au><au>Mumtaz, Khalid</au><au>Stanich, Peter P.</au><au>Hinton, Alice</au><au>Hussan, Hisham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>68</volume><issue>2</issue><spage>554</spage><epage>563</epage><pages>554-563</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract><![CDATA[Background
Colorectal cancer incidence is rising in adults < 50 years old, possibly due to obesity. Non-malignant colorectal conditions are understudied in this population. We hypothesize that developing severe obesity in young adulthood also corresponds with increased hospitalization rates for non-malignant colorectal conditions.
Methods
We examined annual percent change (APC) in the prevalence of obesity in adults < 50 using the 2009–2014 National Health and Nutrition Examination Survey. Using the 2010–2014 Nationwide Readmission Database, we then compared yearly hospitalization trends for various gastrointestinal conditions and their outcomes in adults < 50 with severe obesity vs. no obesity.
Results
The prevalence of obesity increased in adults < 50 years in 2009–2014. This increase was most pronounced for severe obesity (APC of + 12.8%). The rate of patients with severe obesity < 50 who were admitted for gastrointestinal diseases has increased by 7.76% per year in 2010–2014 (
p
< 0.001). This increase was > 10% per year for colorectal conditions such Clostridium difficile infections (APC + 17.3%,
p
= 0.002), inflammatory bowel disease (APC + 13.1%,
p
= 0.001), and diverticulitis (APC + 12.7%,
p
= 0.002). The hospitalization rate for chronic liver diseases and acute pancreatitis also increased by 12.2% and 10.0% per year, respectively (
p
< 0.01). In contrast, young adults without obesity had lower hospitalization rate for most gastrointestinal diseases. Furthermore, adults with no obesity had lower mortality rates for appendicitis, diverticulitis, pancreatitis and chronic liver diseases than adults with severe obesity.
Conclusion
Our data suggest that increased adiposity in young adults is associated with more hospitalization and worse outcomes for infectious/inflammatory gastrointestinal conditions. Future prevention strategies are warranted to ameliorate these trends.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>35704253</pmid><doi>10.1007/s10620-022-07589-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4012-8167</orcidid></addata></record> |
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| subjects | Acute Disease Adult Adults Biochemistry Colorectal Neoplasms - epidemiology Comparative analysis Disease prevention Diverticulitis Gastroenterology Gastrointestinal diseases Hepatology Hospitalization Humans Incidence Liver Liver diseases Medicine Medicine & Public Health Middle Aged Nutrition Surveys Obesity Obesity - epidemiology Obesity, Morbid Oncology Original Article Pancreatitis Statistics Surveys Transplant Surgery Trends Young Adult Young adults |
| title | Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease |
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