Lung vascular changes as biomarkers of severity in systemic sclerosis-associated interstitial lung disease

It has recently become possible to assess lung vascular and parenchymal changes quantitatively in thoracic CT images using automated software tools. We investigated the vessel parameters of patients with SSc, quantified by CT imaging, and correlated them with interstitial lung disease (ILD) features...

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Published in:Rheumatology (Oxford, England) England), 2023-02, Vol.62 (2), p.696-706
Main Authors: Bruni, Cosimo, Occhipinti, Mariaelena, Pienn, Michael, Camiciottoli, Gianna, Bartolucci, Maurizio, Bosello, Silvia Laura, Payer, Christian, Bálint, Zoltán, Larici, Anna Rita, Tottoli, Alessandra, Tofani, Lorenzo, De Lorenzis, Enrico, Lepri, Gemma, Bellando-Randone, Silvia, Spinella, Amelia, Giuggioli, Dilia, Masini, Francesco, Cuomo, Giovanna, Lavorini, Federico, Colagrande, Stefano, Olschewski, Horst, Matucci-Cerinic, Marco
Format: Article
Language:English
Subjects:
Biomarkers
Female
Humans
Lung
Lung Diseases, Interstitial - complications
Lung Diseases, Interstitial - etiology
Middle Aged
Retrospective Studies
Scleroderma, Systemic - complications
Scleroderma, Systemic - diagnostic imaging
Tomography, X-Ray Computed - methods
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Summary:It has recently become possible to assess lung vascular and parenchymal changes quantitatively in thoracic CT images using automated software tools. We investigated the vessel parameters of patients with SSc, quantified by CT imaging, and correlated them with interstitial lung disease (ILD) features. SSc patients undergoing standard of care pulmonary function testing and CT evaluation were retrospectively evaluated. CT images were analysed for ILD patterns and total pulmonary vascular volume (PVV) extents with Imbio lung texture analysis. Vascular analysis (volumes, numbers and densities of vessels, separating arteries and veins) was performed with an in-house developed software. A threshold of 5% ILD extent was chosen to define the presence of ILD, and commonly used cut-offs of lung function were adopted. A total of 79 patients [52 women, 40 ILD, mean age 56.2 (s.d. 14.2) years, total ILD extent 9.5 (10.7)%, PVV/lung volume % 2.8%] were enrolled. Vascular parameters for total and separated PVV significantly correlated with functional parameters and ILD pattern extents. SSc-associated ILD (SSc-ILD) patients presented with an increased number and volume of arterial vessels, in particular those between 2 and 4 mm of diameter, and with a higher density of arteries and veins of
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keac311