Super-Resolution Electrochemical Impedance Imaging With a 512 × 256 CMOS Sensor Array

Super-resolution imaging is a family of techniques in which multiple lower-resolution images can be merged to produce a single image at higher resolution. While super-resolution is often applied to optical systems, it can also be used with other imaging modalities. Here we demonstrate a 512 × 256 CM...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on biomedical circuits and systems 2022-08, Vol.16 (4), p.502-510
Main Authors: Hu, Kangping, Ho, Jason, Rosenstein, Jacob K.
Format: Article
Language:English
Subjects:
Algae
Algorithms
Aquatic plants
Biosensor
Capacitance
Capacitance measurement
Clocks
CMOS
computational imaging
dielectric spectroscopy
electrochemical
Electrochemical impedance spectroscopy
Electrochemistry
Electrodes
Image processing
Image reconstruction
Image resolution
image sensor
Impedance
impedance spectroscopy
impedance tomography
Mathematical models
Pixels
Sensor arrays
Sensors
Spectroscopy
super-resolution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Super-resolution imaging is a family of techniques in which multiple lower-resolution images can be merged to produce a single image at higher resolution. While super-resolution is often applied to optical systems, it can also be used with other imaging modalities. Here we demonstrate a 512 × 256 CMOS sensor array for micro-scale super-resolution electrochemical impedance spectroscopy (SR-EIS) imaging. The system is implemented in standard 180 nm CMOS technology with a 10 \mum × 10 \mum pixel size. The sensor array is designed to measure the mutual capacitance between programmable sets of pixel pairs. Multiple spatially-resolved impedance images can then be computationally combined to generate a super-resolution impedance image. We use finite-element electrostatic simulations to support the proposed measurement approach and discuss straightforward algorithms for super-resolution image reconstruction. We present experimental measurements of sub-cellular permittivity distribution within single green algae cells, showing the sensor's capability to produce microscale impedance images with sub-pixel resolution.
ISSN:1932-4545
1940-9990
DOI:10.1109/TBCAS.2022.3183856