Controversies in rheumatology: maintenance therapy with low-dose glucocorticoids in rheumatoid arthritis

Since the beginning of the use of glucocorticoids in clinical medicine, the risk-benefit ratio of these still very important drugs has been debated. There is no doubt that they produce many desirable therapeutic effects quickly and reliably. However, their potential to cause adverse effects, especia...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2022-12, Vol.62 (1), p.35-41
Main Authors: Buttgereit, Frank, Kvien, Tore K
Format: Article
Language:English
Subjects:
Antirheumatic Agents - adverse effects
Arthritis, Rheumatoid - chemically induced
Arthritis, Rheumatoid - drug therapy
Drug-Related Side Effects and Adverse Reactions
Glucocorticoids - adverse effects
Humans
Rheumatology
Risk Assessment
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Summary:Since the beginning of the use of glucocorticoids in clinical medicine, the risk-benefit ratio of these still very important drugs has been debated. There is no doubt that they produce many desirable therapeutic effects quickly and reliably. However, their potential to cause adverse effects, especially with prolonged use in high doses, limits their applicability. We discuss the arguments against and in favour of maintenance therapy with low-dose glucocorticoids in patients with RA, and present recent studies, assessments and conclusions on this question.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keac355