Basiliximab Does Not Impair Airway Mucociliary Clearance of Rats

Previous studies have shown that immunosuppressive drugs impair the airway mucociliary clearance of rats. However, considering the high specificity of basiliximab (BSX) and the absence of studies reporting its side effects, our aim was to investigate whether BSX, associated or not with triple therap...

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Bibliographic Details
Published in:Inflammation 2022-12, Vol.45 (6), p.2243-2255
Main Authors: Correia, Aristides Tadeu, de Almeida, Francine Maria, Augusto-Cottet, Marcia Cristina, Nolasco, Patrícia, Bento, Afonso Silva Alves, Hirano, Hugo Kenji Matsushima, de Souza, Maria Cecília Ribeiro, dos Santos, Elizabete Silva, de Castro, Júlia Helena Rodrigues, Matsuda, Monique, Pêgo-Fernandes, Paulo Manuel, Pazetti, Rogerio
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell number
Gene expression
Immunology
Immunosuppressive agents
Inflammation
Interleukin 6
Internal Medicine
Leukocytes (mononuclear)
Leukocytes (neutrophilic)
Leukocytes (polymorphonuclear)
Lymphocytes
Monoclonal antibodies
MUC5B gene
Mucin
Original Article
Pathology
Pharmacology/Toxicology
Respiratory tract
Rheumatology
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Summary:Previous studies have shown that immunosuppressive drugs impair the airway mucociliary clearance of rats. However, considering the high specificity of basiliximab (BSX) and the absence of studies reporting its side effects, our aim was to investigate whether BSX, associated or not with triple therapy, impairs the mucociliary system. Forty rats were divided into 4 groups: Control, BSX, Triple, and BSX + Triple. After 15 days of treatment, animals were euthanized and the ciliary beating frequency (CBF), mucociliary transport velocity (MCTV), neutral and acid mucin production, Muc5ac and Muc5b gene expression, inflammatory cell number, and interleukin (IL)-6 concentration were analyzed. CBF and MCTV were lower in Triple and BSX + Triple groups ( p  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-022-01687-0