Surgical treatment of peri-implantitis with or without adjunctive graft material: a systematic review and meta-analysis of randomized controlled trials

• Published in: International journal of oral and maxillofacial surgery 2023-01, Vol.52 (1), p.107-117
• Main Authors: Li, Z.-B., Li, K., Du, M., Ren, S.-B., Yu, Y.
• Format: Article
• Language: English
• Subjects: Alveolar bone grafting; Bone regeneration; Bone substitutes; Humans; Peri-implantitis; Peri-Implantitis - drug therapy; Peri-Implantitis - surgery; Periodontal debridement; Randomized Controlled Trials as Topic; Surgical Flaps
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/j.ijom.2022.05.007

This systematic review and meta-analysis was performed to compare the clinical effect of surgical treatment of peri-implantitis alone or in combination with graft material. Literature searches were conducted up to June 20, 2020. Randomized controlled trials (RCTs) comparing the clinical effects of open flap debridement (OFD) alone and OFD with adjunctive graft materials for the treatment of peri-implantitis were included. Probing depth (PD) changes and marginal bone level (MBL) changes were assessed and expressed as the standardized mean difference (SMD) with 95% confidence interval (CI). Subgroup analyses and sensitivity analyses were conducted. The search yielded 7419 articles, five of which were analysed quantitatively. The adjunctive use of graft materials in OFD did not provide additional PD improvements (SMD 0.46, 95% CI −0.13 to 1.05; P = 0.13), but did yield additional MBL improvements (SMD 1.04, 95% CI 0.71–1.37; P