Now you see me, now you don't: Isolated central nervous system recurrence of CD19‐negative diffuse large B‐cell lymphoma following CD19‐directed CAR T‐cell treatment

The authors discuss a case of CD19‐negative diffuse large B‐cell lymphoma with central nervous system relapse following CD19‐directed CAR T‐cell treatment. Absence of CD19 expression by the tumour cells presented a challenge for flow cytometry evaluation.

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Bibliographic Details
Published in:Cytopathology (Oxford) 2022-11, Vol.33 (6), p.757-759
Main Authors: Gokozan, Hamza N., Ouseph, Madhu M., Carniello, Jose V. Scarpa, Besien, Koen Van, Patel, Sanjay S.
Format: Article
Language:English
Subjects:
B-cell lymphoma
CAR T‐cell Therapy
CD19 antigen
Central nervous system
CNS Relapse
Cytopathology
Diffuse Large B‐cell Lymphoma
Flow cytometry
Tumors
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Description
Summary:The authors discuss a case of CD19‐negative diffuse large B‐cell lymphoma with central nervous system relapse following CD19‐directed CAR T‐cell treatment. Absence of CD19 expression by the tumour cells presented a challenge for flow cytometry evaluation.
ISSN:0956-5507
1365-2303
DOI:10.1111/cyt.13160