Pediatric Cardiac Magnetic Resonance Reference Values for Biventricular Volumes Derived From Different Contouring Techniques

• Published in: Journal of magnetic resonance imaging 2023-03, Vol.57 (3), p.774-788
• Main Authors: Voges, Inga, Caliebe, Amke, Hinz, Sophia, Boroni Grazioli, Simona, Gabbert, Dominik D., Daubeney, Piers E. F., Uebing, Anselm S., Pennell, Dudley J., Krupickova, Sylvia
• Format: Article
• Language: English
• Subjects: Blood volume; Cardiovascular disease; Cardiovascular diseases; Child; Children; Congenital diseases; Contouring; contouring methods; Field strength; Gender; Heart Defects, Congenital; Heart diseases; Heart Ventricles - diagnostic imaging; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging, Cine - methods; Magnetic Resonance Spectroscopy; Male; Methods; Muscles; normal values; Pediatrics; Reference Values; Regression analysis; Regression models; Reproducibility of Results; Retrospective Studies; Statistical analysis; Statistical tests; Stroke Volume; Ventricle; Ventricular Function, Left; ventricular volumes; Weight
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.28299

Background Measurement of ventricular volumes and function using MRI is an important tool in pediatric congenital heart disease. However, normal values for children are sparce and analysis methods are inconsistent. Purpose To propose biventricular reference values in children for two MRI postprocessing (contouring) techniques. Study Type Retrospective. Subjects A total of 154 children from two institutions (13.9 ± 2.8 years; 101 male) that were referred for a clinical MRI study. Field Strength/Sequence 1.5 T; balanced steady‐state free precession (bSSFP) sequence. Assessment Left ventricular (LV) and right ventricular (RV) end‐diastolic and end‐systolic volumes (LVEDV, LVESV, RVEDV, RVESV) and end‐diastolic and end‐systolic myocardial mass (LVEDMM, LVESMM, RVEDMM, RVESMM) were measured from short‐axis images using two contouring techniques: 1) papillary muscles, trabeculations and the moderator band were included in the ventricular blood volume and excluded from the myocardial mass, 2) papillary muscles, trabeculations and the moderator band were excluded from the ventricular volume and included in the ventricular mass. Statistical Tests Univariable and multivariable linear regression models were used to evaluate relationships between sex, weight, height, body surface area (BSA) and age and volumetric results. Reference graphs and tables were created with the LMS‐method. Contouring techniques were compared by intraclass correlation, regression analysis and Bland–Altman plots. A P value