Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat

Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that leaves extract induces both an antioxidative action and an gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by are not known. Th...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2023-03, Vol.37 (5), p.819-822
Main Authors: Salinas-Nolasco, Cristina, Barragán-Zarate, Gabriela Soledad, Lagunez-Rivera, Luicita, Solano, Rodolfo, Favari, Liliana, Jiménez-Andrade, Juan Miguel, Chávez-Piña, Aracely Evangelina
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - pharmacology
Antioxidants - pharmacology
Biomarkers
Epithelium
Gastric Mucosa
Indomethacin
Indomethacin - adverse effects
Inflammation
Injuries
Leaves
Leukocytes
Leukotriene B4 - adverse effects
Nitric oxide
Nitric Oxide - pharmacology
Oral administration
Plant extracts
Plant Extracts - therapeutic use
Plant Leaves
Rats
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Stomach Ulcer - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that leaves extract induces both an antioxidative action and an gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by are not known. Thus, the aim of this study is to determine whether extract modifies anti-inflammatory and antioxidative biomarkers in an model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and leaf extract. Our results suggest that the gastroprotective effect of leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of leaves extract.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2089880