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Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat
Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that leaves extract induces both an antioxidative action and an gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by are not known. Th...
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| Published in: | Natural product research 2023-03, Vol.37 (5), p.819-822 |
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| Main Authors: | , , , , , , |
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| container_end_page | 822 |
| container_issue | 5 |
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| container_title | Natural product research |
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| creator | Salinas-Nolasco, Cristina Barragán-Zarate, Gabriela Soledad Lagunez-Rivera, Luicita Solano, Rodolfo Favari, Liliana Jiménez-Andrade, Juan Miguel Chávez-Piña, Aracely Evangelina |
| description | Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that
leaves extract induces both an
antioxidative action and an
gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by
are not known. Thus, the aim of this study is to determine whether
extract modifies anti-inflammatory and antioxidative biomarkers in an
model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and
leaf extract. Our results suggest that the gastroprotective effect of
leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of
leaves extract. |
| doi_str_mv | 10.1080/14786419.2022.2089880 |
| format | article |
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leaves extract induces both an
antioxidative action and an
gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by
are not known. Thus, the aim of this study is to determine whether
extract modifies anti-inflammatory and antioxidative biomarkers in an
model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and
leaf extract. Our results suggest that the gastroprotective effect of
leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of
leaves extract.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2022.2089880</identifier><identifier>PMID: 35722687</identifier><language>eng</language><publisher>England: Taylor & Francis Ltd</publisher><subject>Animals ; Anti-Ulcer Agents - pharmacology ; Antioxidants - pharmacology ; Biomarkers ; Epithelium ; Gastric Mucosa ; Indomethacin ; Indomethacin - adverse effects ; Inflammation ; Injuries ; Leaves ; Leukocytes ; Leukotriene B4 - adverse effects ; Nitric oxide ; Nitric Oxide - pharmacology ; Oral administration ; Plant extracts ; Plant Extracts - therapeutic use ; Plant Leaves ; Rats ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy ; Stomach Ulcer - prevention & control</subject><ispartof>Natural product research, 2023-03, Vol.37 (5), p.819-822</ispartof><rights>2022 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-ffde130ed84ecb6054c61cab650c7de525ccec9edc3c2964b5e1808e7eb48c863</citedby><cites>FETCH-LOGICAL-c384t-ffde130ed84ecb6054c61cab650c7de525ccec9edc3c2964b5e1808e7eb48c863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35722687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salinas-Nolasco, Cristina</creatorcontrib><creatorcontrib>Barragán-Zarate, Gabriela Soledad</creatorcontrib><creatorcontrib>Lagunez-Rivera, Luicita</creatorcontrib><creatorcontrib>Solano, Rodolfo</creatorcontrib><creatorcontrib>Favari, Liliana</creatorcontrib><creatorcontrib>Jiménez-Andrade, Juan Miguel</creatorcontrib><creatorcontrib>Chávez-Piña, Aracely Evangelina</creatorcontrib><title>Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that
leaves extract induces both an
antioxidative action and an
gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by
are not known. Thus, the aim of this study is to determine whether
extract modifies anti-inflammatory and antioxidative biomarkers in an
model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and
leaf extract. Our results suggest that the gastroprotective effect of
leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of
leaves extract.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Biomarkers</subject><subject>Epithelium</subject><subject>Gastric Mucosa</subject><subject>Indomethacin</subject><subject>Indomethacin - adverse effects</subject><subject>Inflammation</subject><subject>Injuries</subject><subject>Leaves</subject><subject>Leukocytes</subject><subject>Leukotriene B4 - adverse effects</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>Oral administration</subject><subject>Plant extracts</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Rats</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - prevention & control</subject><issn>1478-6419</issn><issn>1478-6427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkcuOFCEUhonROBd9BA2JGzc1AsWtljoZL0knGjOuCQWnbHqqYQRqLs_iy0qnu2fhBg7k-3_O4UfoDSUXlGjygXKlJafDBSOMtUUPWpNn6HR330nO1POnmg4n6KyUDSGMCiFeopNeKMakVqfo7880A04TXl1_4thGj2OoOTicHoIHHCKua8C_bak53eZUwdVwBximqVU73Y-cSkPcGiy-sfk-xHITAp7B3kHB8FCzbeDBJ0SftlDX1oXYtcPiwO_N24shbpb8eESzra_Qi8nOBV4f9nP06_PV9eXXbvX9y7fLj6vO9ZrXbpo80J6A1xzcKIngTlJnRymIUx4EE86BG8C73rFB8lEA1USDgpFrp2V_jt7vfduAfxYo1WxDcTDPNkJaimFSacUJ431D3_2HbtKSY-vOMKUUlWTgQ6PEnnLtc0qGydzmsLX50VBidumZY3pml545pNd0bw_uy7gF_6Q6xtX_A06qmBc</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Salinas-Nolasco, Cristina</creator><creator>Barragán-Zarate, Gabriela Soledad</creator><creator>Lagunez-Rivera, Luicita</creator><creator>Solano, Rodolfo</creator><creator>Favari, Liliana</creator><creator>Jiménez-Andrade, Juan Miguel</creator><creator>Chávez-Piña, Aracely Evangelina</creator><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202303</creationdate><title>Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat</title><author>Salinas-Nolasco, Cristina ; Barragán-Zarate, Gabriela Soledad ; Lagunez-Rivera, Luicita ; Solano, Rodolfo ; Favari, Liliana ; Jiménez-Andrade, Juan Miguel ; Chávez-Piña, Aracely Evangelina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-ffde130ed84ecb6054c61cab650c7de525ccec9edc3c2964b5e1808e7eb48c863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Biomarkers</topic><topic>Epithelium</topic><topic>Gastric Mucosa</topic><topic>Indomethacin</topic><topic>Indomethacin - adverse effects</topic><topic>Inflammation</topic><topic>Injuries</topic><topic>Leaves</topic><topic>Leukocytes</topic><topic>Leukotriene B4 - adverse effects</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>Oral administration</topic><topic>Plant extracts</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Rats</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salinas-Nolasco, Cristina</creatorcontrib><creatorcontrib>Barragán-Zarate, Gabriela Soledad</creatorcontrib><creatorcontrib>Lagunez-Rivera, Luicita</creatorcontrib><creatorcontrib>Solano, Rodolfo</creatorcontrib><creatorcontrib>Favari, Liliana</creatorcontrib><creatorcontrib>Jiménez-Andrade, Juan Miguel</creatorcontrib><creatorcontrib>Chávez-Piña, Aracely Evangelina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salinas-Nolasco, Cristina</au><au>Barragán-Zarate, Gabriela Soledad</au><au>Lagunez-Rivera, Luicita</au><au>Solano, Rodolfo</au><au>Favari, Liliana</au><au>Jiménez-Andrade, Juan Miguel</au><au>Chávez-Piña, Aracely Evangelina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat</atitle><jtitle>Natural product research</jtitle><addtitle>Nat Prod Res</addtitle><date>2023-03</date><risdate>2023</risdate><volume>37</volume><issue>5</issue><spage>819</spage><epage>822</epage><pages>819-822</pages><issn>1478-6419</issn><eissn>1478-6427</eissn><abstract>Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that
leaves extract induces both an
antioxidative action and an
gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by
are not known. Thus, the aim of this study is to determine whether
extract modifies anti-inflammatory and antioxidative biomarkers in an
model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and
leaf extract. Our results suggest that the gastroprotective effect of
leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of
leaves extract.</abstract><cop>England</cop><pub>Taylor & Francis Ltd</pub><pmid>35722687</pmid><doi>10.1080/14786419.2022.2089880</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Natural product research, 2023-03, Vol.37 (5), p.819-822 |
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| source | Taylor and Francis Science and Technology Collection |
| subjects | Animals Anti-Ulcer Agents - pharmacology Antioxidants - pharmacology Biomarkers Epithelium Gastric Mucosa Indomethacin Indomethacin - adverse effects Inflammation Injuries Leaves Leukocytes Leukotriene B4 - adverse effects Nitric oxide Nitric Oxide - pharmacology Oral administration Plant extracts Plant Extracts - therapeutic use Plant Leaves Rats Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - prevention & control |
| title | Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat |
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