Significance of interstitial fibrosis and p16 in papillary thyroid carcinoma

We enrolled 264 patients with papillary thyroid carcinoma (PTC). We performed immunohistochemical detection of p16 and determined the degree of interstitial fibrosis (IF). The expression of p16 was associated with pathological tumor–node–metastasis (pTNM) stage and age (p < 0.05). The cancer-spec...

Full description

Saved in:
Bibliographic Details
Published in:ENDOCRINE JOURNAL 2022, Vol.69(10), pp.1253-1259
Main Authors: Wang, Hong-Qun, Li, Ying, Song, Xin, Ma, Ya-Qi, Li, Jin-Long, Li, Ying-Xue, Wang, Gao-Fei, Liu, Peng, Liu, Ping-Li, Cao, Shen, Shi, Huai-Yin
Format: Article
Language:English
Subjects:
Fibrosis
Interstitial fibrosis
Metastases
P16
Papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC)
Prognosis
Survival
Thyroid
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We enrolled 264 patients with papillary thyroid carcinoma (PTC). We performed immunohistochemical detection of p16 and determined the degree of interstitial fibrosis (IF). The expression of p16 was associated with pathological tumor–node–metastasis (pTNM) stage and age (p < 0.05). The cancer-specific survival (CSS) was longer in p16-negative patients (195.73 vs. 181.78 months, p = 0.007). p16 was significantly related to the degree of IF (r = 0.130, p = 0.035). PTC patients with no or mild fibrosis tended to have a larger tumor (p = 0.045). The degree of fibrosis was related to the proportion of papillary structure components (p = 0.025). Univariate and multivariate survival analyses showed that relapse-free survival (RFS) was longer in patients with moderate/severe IF (p < 0.05). In summary, p16 was correlated with prognosis and IF of PTC. Patients with moderate/severe IF tend to have better prognosis in RFS.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ22-0010