miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders

The heterogeneity of psychiatric disorders and the lack of reliable biomarkers for prediction and treatments follow-up pose difficulties towards recognition and understanding of the molecular basis of psychiatric diseases. However, several studies based on NGS approaches have shown that miRNAs could...

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Bibliographic Details
Published in:The pharmacogenomics journal 2022-07, Vol.22 (4), p.211-222
Main Authors: Tsermpini, Evangelia Eirini, Kalogirou, Christina I., Kyriakopoulos, George C., Patrinos, George P., Stathopoulos, Constantinos
Format: Article
Language:English
Subjects:
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Bioinformatics
Biomarkers
Biomedical and Life Sciences
Biomedicine
Bipolar disorder
Gene Expression
Human Genetics
Mental disorders
MicroRNAs
Oncology
Pharmacogenomics
Pharmacotherapy
Psychopharmacology
Psychotropic drugs
Review Article
Schizophrenia
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Summary:The heterogeneity of psychiatric disorders and the lack of reliable biomarkers for prediction and treatments follow-up pose difficulties towards recognition and understanding of the molecular basis of psychiatric diseases. However, several studies based on NGS approaches have shown that miRNAs could regulate gene expression during onset and disease progression and could serve as potential diagnostic and pharmacogenomics biomarkers during treatment. We provide herein a detailed overview of circulating miRNAs and their expression profiles as biomarkers in schizophrenia, bipolar disorder and major depressive disorder and their role in response to specific treatments. Bioinformatics analysis of miR-34a, miR-106, miR-134 and miR-132, which are common among SZ, BD and MDD patients, showed brain enrichment and involvement in the modulation of critical signaling pathways, which are often deregulated in psychiatric disorders. We propose that specific miRNAs support accurate diagnosis and effective precision treatment of psychiatric disorders.
ISSN:1470-269X
1473-1150
DOI:10.1038/s41397-022-00283-7