An EfficientNet-based modified sigmoid transform for enhancing dermatological macro-images of melanoma and nevi skin lesions

• Published in: Computer methods and programs in biomedicine 2022-07, Vol.222, p.106935-106935, Article 106935
• Main Authors: Venugopal, Vipin, Joseph, Justin, Vipin Das, M., Kumar Nath, Malaya
• Format: Article
• Language: English
• Subjects: Convolutional neural network; Deep learning; Image enhancement; Macro-images; Sigmoid transform; Skin lesions
• ISSN: 0169-2607; 1872-7565
• DOI: 10.1016/j.cmpb.2022.106935

•An EfficientNet-based modified sigmoid transform for enhancing the contrast between lesion and background regions on dermatological macro-images.•The modified sigmoid transform has provisions for fixing the boundary that divides the pixel values into lesion and background regions.•Helps to improve the accuracy of segmenting the skin lesions.•Practical application as a pre-processing step in automated tools for detecting skin cancer from dermatological macro-images. [Display omitted] Background and objective: During the initial stages, skin lesions may not have sufficient intensity difference or contrast from the background region on dermatological macro-images. The lack of proper light exposure at the time of capturing the image also reduces the contrast. Low contrast between lesion and background regions adversely impacts segmentation. Enhancement techniques for improving the contrast between lesion and background skin on dermatological macro-images are limited in the literature. An EfficientNet-based modified sigmoid transform for enhancing the contrast on dermatological macro-images is proposed to address this issue. Methods: A modified sigmoid transform is applied in the HSV color space. The crossover point in the modified sigmoid transform that divides the macro-image into lesion and background is predicted using a modified EfficientNet regressor to exclude manual intervention and subjectivity. The Modified EfficientNet regressor is constructed by replacing the classifier layer in the conventional EfficientNet with a regression layer. Transfer learning is employed to reduce the training time and size of the dataset required to train the modified EfficientNet regressor. For training the modified EfficientNet regressor, a set of value components extracted from the HSV color space representation of the macro-images in the training dataset is fed as input. The corresponding set of ideal crossover points at which the values of Dice similarity coefficient (DSC) between the ground-truth images and the segmented output images obtained from Otsu’s thresholding are maximum, is defined as the target. Results: On images enhanced with the proposed framework, the DSC of segmented results obtained by Otsu’s thresholding increased from 0.68 ± 0.34 to 0.81 ± 0.17. Conclusions: The proposed algorithm could consistently improve the contrast between lesion and background on a comprehensive set of test images, justifying its applications in automated analysis of dermatol