New Cytochalasin Derivatives from Deep‐Sea Cold Seep‐Derived Endozoic Fungus Curvularia verruculosa CS‐129

Two new antimicrobial cytochalasin derivatives, 6β,7β‐epoxydeoxaphomin C (1) and 12‐hydroxydeoxaphomin C (2), a new natural occurring product 24‐nor‐cytochalasin B (3), together with two related known analogs (4–5) were isolated and identified from an endozoic fungus Curvularia verruculosa CS‐129, i...

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Published in:Chemistry & biodiversity 2022-08, Vol.19 (8), p.e202200550-n/a
Main Authors: Hu, Xue‐Yi, Li, Xiao‐Ming, Yang, Sui‐Qun, Wang, Bin‐Gui, Meng, Ling‐Hong
Format: Article
Language:English
Subjects:
Antibacterial activity
antimicrobial activity
Antimicrobial agents
Curvularia
Curvularia verruculosa
Cytochalasin B
cytochalasin derivatives
endozoic fungus
Fungi
marine natural products
Shellfish
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description Two new antimicrobial cytochalasin derivatives, 6β,7β‐epoxydeoxaphomin C (1) and 12‐hydroxydeoxaphomin C (2), a new natural occurring product 24‐nor‐cytochalasin B (3), together with two related known analogs (4–5) were isolated and identified from an endozoic fungus Curvularia verruculosa CS‐129, isolated from the deep‐sea squat lobster Shinkaia crosnieri which was collected in cold seep region of south China sea. The structures of new compounds were elucidated on the basis of detailed spectroscopic analysis and ECD calculation. The spectroscopic data of 24‐nor‐cytochalasin B (3) were reported for the first time. All compounds were tested for their antibacterial activities against human and aquatic pathogenic bacteria.
doi_str_mv 10.1002/cbdv.202200550
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subjects Antibacterial activity
antimicrobial activity
Antimicrobial agents
Curvularia
Curvularia verruculosa
Cytochalasin B
cytochalasin derivatives
endozoic fungus
Fungi
marine natural products
Shellfish
title New Cytochalasin Derivatives from Deep‐Sea Cold Seep‐Derived Endozoic Fungus Curvularia verruculosa CS‐129
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