Macrophage functions measured by magnetic microparticles in vivo and in vitro

Monodisperse ferrimagnetic iron-oxide particles of 1.4 μm geometric diameter were used to study alveolar macrophage functions (phagocytosis, phagosome transport) and cytoskeletal integrity in healthy subjects and in patients with idiopathic pulmonary fibrosis as well as in cultured macrophages. Dysf...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2001, Vol.225 (1), p.218-225
Main Authors: Möller, Winfried, Kreyling, Wolfgang G., Kohlhäufl, Martin, Häussinger, Karl, Heyder, Joachim
Format: Article
Language:English
Subjects:
Alveolar macrophage
Biological and medical sciences
Cytoskeleton
Hematology
Investigative techniques, diagnostic techniques (general aspects)
J774A.1 macrophage
Lung fibrosis
Macrophage function
Magnetic iron-oxide microparticles
Magnetopneumography
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phagocytosis
Phagosome motion
Smoker
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Summary:Monodisperse ferrimagnetic iron-oxide particles of 1.4 μm geometric diameter were used to study alveolar macrophage functions (phagocytosis, phagosome transport) and cytoskeletal integrity in healthy subjects and in patients with idiopathic pulmonary fibrosis as well as in cultured macrophages. Dysfunctions in phagocytosis, in phagosome transport and cytoskeletal integrity correlated with an impaired alveolar clearance and could be induced in vitro by cytoskeletal drugs.
ISSN:0304-8853
DOI:10.1016/S0304-8853(00)01261-0