Immobilization of bisphosphonates on surface modified titanium

The efficiency of surface modifications on the immobilization of bisphosphonates on titanium was investigated with Ca-ion implantation and thin hydroxyapatite coatings. The ALP activity of osteoblastic cells and the inhibitory effects on the initial adherence of P. gingivalis were also evaluated usi...

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Bibliographic Details
Published in:Biomaterials 2001-04, Vol.22 (7), p.709-715
Main Authors: Yoshinari, M., Oda, Y., Ueki, H., Yokose, S.
Format: Article
Language:English
Subjects:
Animals
Bacterial Adhesion
Biocompatible Materials
Biological and medical sciences
Bisphosphonate
Calcium
Cells, Cultured
Dental Implants
Diphosphonates
Humans
Immobilization
Materials Testing
Medical sciences
Osseointegration
Osteoblasts - cytology
Porphyromonas gingivalis - pathogenicity
Rats
Spectrometry, X-Ray Emission
Surface modification
Surface Properties
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Titanium
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Summary:The efficiency of surface modifications on the immobilization of bisphosphonates on titanium was investigated with Ca-ion implantation and thin hydroxyapatite coatings. The ALP activity of osteoblastic cells and the inhibitory effects on the initial adherence of P. gingivalis were also evaluated using bisphosphonate-immobilized titanium. X-ray photoelectron spectroscopy analysis suggested that titanium surfaces modified with Ca-ion implantation and thin hydroxyapatite coatings caused the immobilization of bisphosphonate on titanium plates. The ALP activity of osteoblastic cells cultured on plates immobilized with bisphosphonate was almost the same as that of cells cultured on titanium plates, indicating that the bisphosphonate-immobilization showed no toxic effect on osteoblastic cells, and that it provides a favorable micro-environment with osteogenetic ability. Data of the adherence of oral bacteria showed that a bisphosphonate-immobilized titanium surface inhibited the initial adherence of P. gingivalis. These results indicate that the immobilization of bisphosphonates on titanium modified with Ca-ion implantation and thin hydroxyapatite coatings are useful for dental implants.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(00)00234-9