A comparison of cerebral amyloid angiopathy in the cerebellum and CAA‐positive occipital lobe of 60 brains from routine autopsies

• Published in: Neuropathology 2022-12, Vol.42 (6), p.483-487
• Main Authors: Okamoto, Koichi, Amari, Masakuni, Ikeda, Masaki, Fukuda, Toshio, Suzuki, Keiji, Takatama, Masamitsu
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; amyloid‐β plaque; Autopsies; Brain - pathology; Cerebellum; Cerebral amyloid angiopathy; Cerebral Amyloid Angiopathy - pathology; Humans; Occipital lobe; Occipital Lobe - pathology; pathology; Plaque, Amyloid - pathology; Senile plaques; Vascular diseases; β-Amyloid
• ISSN: 0919-6544; 1440-1789
• DOI: 10.1111/neup.12838

We semiquantitatively compared the frequency and severity of cerebral amyloid angiopathy (CAA) in the cerebellum and CAA‐positive occipital lobe of 60 subjects from routine autopsies. In the 60 subjects with a CAA‐positive occipital lobe, cerebellar CAA was observed in 29 subjects (48.3%), and the severity of cerebellar CAA was relatively mild compared with occipital lobe CAA. Capillary CAA was observed in the occipital lobe of 12 subjects and the cerebellum of three subjects. CAA‐related vasculopathies were observed in the occipital lobe of 15 subjects and the cerebellum of two subjects. The severity of CAA‐related vasculopathy was mild in both of these subjects. Amyloid‐β plaques were observed in the occipital lobe of 54 subjects (90%) and the cerebellum of 16 subjects (26.7%). The severity of amyloid‐β plaques in the cerebellum was mild compared with the occipital lobe. In summary, we confirmed that cerebellar CAA is frequently observed in the cerebellum but with a lower severity than CAA in the occipital lobe.