Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity

• Published in: Food chemistry 2022-11, Vol.394, p.133500-133500, Article 133500
• Main Authors: Hu, Shanshan, Hu, Changhua, Luo, Liyong, Zhang, Haotian, Zhao, Sibo, Liu, Zhonghua, Zeng, Liang
• Format: Article
• Language: English
• Subjects: adipose tissue; Cinnabarinic acid; circadian rhythm disruption; gut microbes; Pu-erh tea
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2022.133500

•CRD induced metabolic disorders and obesity in healthy mice.•Pu-erh tea promoted the production of Cinnabarinic acid (CA).•CA reshaped ut microbes and improved the production of short-chain fatty acids.•CA targeted the expression of adipose tissue receptor proteins.•Pu-erh tea has the potential to improve CRD. Obesity is one of the circadian rhythm disorders (CRD)-mediated metabolic disorder syndromes. Pu-erh tea is a viable dietary intervention for CRD, however its effect on CRD-induced obesity is unclear. Here, we found that Pu-erh tea improved obesity in CRD-induced mice, which stemmed from the production of Cinnabarinic acid (CA). CA promoted adipose tissue lipolysis and thermogenic response (HSL, ATGL, Pparα, CKB, UCP1) and increased adipocyte sensitivity to hormones and neurotransmitters by targeting the expression of adipose tissue receptor proteins (Q6KAT8, P51655, A2AKQ0, M0QWX7, Q6ZQ33, and mGluR4). This improved mitochondrial activity and facilitated adipose tissue metabolic processes, thereby accelerating glucolipid metabolism. Also, CA-induced alterations in gut microbes and short-chain fatty acids further improved CRD-mediated lipid accumulation. These results suggest that the increase of CA caused by Pu-erh tea, targeted to adipose tissue via the metabolite-blood circulation-adipose tissue axis, maybe a key mechanism for reducing the development of CRD-induced obesity.