Risk of hepatocellular carcinoma after sustained virologic response in hepatitis C virus patients without advanced liver fibrosis

Aim Hepatocellular carcinoma (HCC) after sustained virologic response (SVR) has been observed even in hepatitis C virus (HCV) patients without advanced liver fibrosis. Identifying predictors for HCC incidence in patients without advanced liver fibrosis will enable efficient post‐SVR HCC surveillance...

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Published in:Hepatology research 2022-10, Vol.52 (10), p.824-832
Main Authors: Tahata, Yuki, Sakamori, Ryotaro, Yamada, Ryoko, Kodama, Takahiro, Hikita, Hayato, Nozaki, Yasutoshi, Oshita, Masahide, Hiramatsu, Naoki, Miyazaki, Masanori, Mita, Eiji, Yamamoto, Keiji, Ohkawa, Kazuyoshi, Kaneko, Akira, Ito, Toshifumi, Doi, Yoshinori, Yakushijin, Takayuki, Hijioka, Taizo, Fukui, Hiroyuki, Imanaka, Kazuho, Yoshida, Yuichi, Yamada, Yukinori, Tatsumi, Tomohide, Takehara, Tetsuo
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
chronic hepatitis C
direct‐acting antiviral
Fibrosis
Hepatitis C
Hepatocellular carcinoma
Liver
Liver cancer
liver fibrosis
Multivariate analysis
Patients
Surveillance
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Summary:Aim Hepatocellular carcinoma (HCC) after sustained virologic response (SVR) has been observed even in hepatitis C virus (HCV) patients without advanced liver fibrosis. Identifying predictors for HCC incidence in patients without advanced liver fibrosis will enable efficient post‐SVR HCC surveillance. This study aimed to develop a scoring system to predict the incidence of HCC after SVR in HCV patients without advanced liver fibrosis. Methods A total of 1682 HCV patients without advanced liver fibrosis (defined as Fibrosis‐4 index
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.13806