Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder

Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated with short telomere length (TL). This study was conducted to examine the relationship of TL to AUD and determine whether single...

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Published in:Mechanisms of ageing and development 2022-09, Vol.206, p.111693-111693, Article 111693
Main Authors: Llorente, Hernán, Perez-Rivera, Jose-Angel, Perez-Nieto, María, Cieza-Borrella, Clara, Pastor, Isabel, Novo-Veleiro, Ignacio, Fernández-Mateos, Javier, Chamorro, Antonio-Javier, Crecente-Otero, Patricia, Laso, Francisco-Javier, González-Sarmiento, Rogelio, Marcos, Miguel
Format: Article
Language:English
Subjects:
Alcohol use disorder
Alcoholism
Genetic polymorphism
Telomerase
Telomere
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Summary:Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated with short telomere length (TL). This study was conducted to examine the relationship of TL to AUD and determine whether single nucleotide polymorphisms (SNPs) in TERC and TERT modulate this association. For this purpose, we genotyped TERC SNPs rs2293607, rs12696304, and rs16847897 and TERT SNPs rs2735940, rs2736100, and rs2736098 in 308 male patients with AUD and 255 sex-matched healthy controls and measured TL in a subset of 99 patients and 99 controls paired by age and smoking status. Our results showed that the mean TL was shorter in patients with AUD than in controls. The area under the ROC curve was 0.70 (P 
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2022.111693