Effectiveness of induction therapy with exclusive enteral nutrition in pediatric Crohn's disease

• Published in: Zhongguo dang dai er ke za zhi 2022-06, Vol.24 (6), p.626-630
• Main Authors: Luo, You-You, Fang, You-Hong, Yu, Jin-Dan, Xu, Luo-Jia, Sun, Ming-Fang, Cheng, Qi, Chen, Jie
• Format: Article
• Language: Chinese
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2201065

OBJECTIVESTo evaluate the effectiveness of induction therapy with exclusive enteral nutrition (EEN) in pediatric Crohn's disease (CD).METHODSA retrospective analysis was performed on the medical data of 62 children with CD who received EEN in Children's Hospital, Zhejiang University School of Medicine, from March 2013 to August 2021. The medical data included general information and height, weight, Pediatric Crohn's Disease Activity Index (PCDAI), Crohn's Disease Endoscopic Index of Severity, C-reactive protein, erythrocyte sedimentation rate, and serum albumin level before treatment and after 8 weeks of treatment. The changes in the above indicators were compared before and after treatment.RESULTSAmong the 62 children with CD, there were 39 boys (63%) and 23 girls (37%), with a mean age of (11.9±3.0) years at diagnosis. Among the 55 children who completed EEN treatment for at least 8 weeks, 48 (87%) achieved clinical remission at week 8. PCDAI at week 8 was significantly lower than that before treatment (P